Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Magnesium
Selected research topic
Sleep
Some measured outcomes improved in human comparison studies. Read these findings with their populations and conditions.
Some findings concern patients or people with a deficiency.
- Publications for this topic
- 2
- Human comparison publications
- 1
- Publications needing review
- 0
Findings in the studies
Insomnia symptoms
About this measure
Insomnia Severity Index (ISI)
- A better result than the comparison group was reported.Patient group · Single ingredient · 8 weeks
Measurement and study conditions
- Study type
- Randomized controlled trial: subjects were randomly assigned to groups for comparison.
- Study population
- Human participants · Patient group
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: magnesium versus placebo
- Additional measurement information
- Primary outcome
- Measurement time
- 8 weeks
Sleep onset latency
Research with unclear study subject or type
- The study reported improvement in this measurement.
What the comparison group used was not confirmed.
Single ingredientMeasurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: Patient group. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups.
- Measurement time
- Not confirmed.
Total sleep time
Research with unclear study subject or type
- No clear difference in this measurement was found between the compared groups.Single ingredient · post-intervention
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: Patient group. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: oral magnesium versus placebo
- Additional measurement information
- Secondary outcome
- Measurement time
- post-intervention
Representative outcome and study details
Human studies reported between-group improvement in Insomnia symptoms.
Single-ingredient studies · Human studies · Includes patient groups · between-group comparison
1 publications linked to this result
Insomnia Severity Index (ISI)
- Route, form, dose, or population details are incomplete, so the findings cannot be confirmed as directly comparable.
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: B
The 56.0 evidence score includes 0 independent human studies and 0 clinical studies in the representative benefit area. The B tier remains conservative because of limited repetition across independent human clinical studies, too few clinical findings with an explicit effect direction.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 50
Papers linked to this topic 2 · distinct papers 2 · papers with a confirmed human comparison 1 · papers needing additional review 0
A publication may appear in more than one count. These numbers should not be added. Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
- Insomnia symptoms (Insomnia Severity Index (ISI)): Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1
- Sleep onset latency: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- Total sleep time: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
What the research found
ISI score
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Sleep onset latency
The study reported improvement in this measurement.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Total sleep time
No clear difference in this measurement was found between the compared groups.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
No reviewed caution rules are available yet. Reported caution findings are shown below.
Review 5 combination findings and 0 findings that outperformed an ingredient alone.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Side effects reported with this ingredient alone
Symptoms or adverse events reported in studies without another active ingredient.
diarrhea leading to study discontinuation (tolerability)1 papers
In the randomized trial, the magnesium oxide group had a higher dropout rate than control (27% vs 17%), primarily due to diarrhea.Human studies · Randomized controlled trialReported improvements with combinations
Combination findings are grouped by how the study compared them. This is not a recommendation to combine ingredients.
Combinations with reported improvement
The combination showed improvement, but each ingredient's contribution is unclear.
비타민 B6In subjects with severe/extremely severe stress, the combination of magnesium and vitamin B6 resulted in a 24% greater improvement compared to magnesium alone (p=0.0203).
비타민 DCo-supplementation with Vitamin D and Magnesium resulted in significant improvements in behavioral function and mental health scores compared to placebo.
MelatoninCombined melatonin and magnesium supplementation was more effective in improving serum levels of insulin compared to baseline.
CholineCo-supplementation of choline and magnesium was more effective in improving inflammation and endothelial dysfunction than either alone.
아연Co-supplementation with magnesium oxide and zinc sulfate resulted in significant improvements in glycemic control, lipid profiles, and inflammatory markers compared to placebo.