Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Vitamin B6
Selected research topic
Migraine and pain
Findings differ across measurements or study conditions. The results below keep them separate.
Findings from a combination study cannot be attributed to this ingredient alone.
Some findings concern patients or people with a deficiency.
- Publications for this topic
- 3
- Human comparison publications
- 2
- Publications needing review
- 0
Findings in the studies
breast pain severity
Publications linked to this measurement: 1
- No clear difference from the comparison group was found.Patient group · Single ingredient · two menstrual cycles
Measurement and study conditions
- Study type
- Randomized controlled trial: subjects were randomly assigned to groups for comparison.
- Study population
- Human participants · Patient group
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: Vitamin B6 vs vitamin E active comparator
- Additional measurement information
- Primary outcome
- Measurement time
- two menstrual cycles
frequency of headache attacks
Publications linked to this measurement: 1
- A better result than the comparison group was reported.
What the comparison group used was not confirmed.
Patient group · Single ingredientMeasurement and study conditions
- Study type
- Randomized controlled trial: subjects were randomly assigned to groups for comparison.
- Study population
- Human participants · Patient group
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups.
- Measurement time
- Not confirmed.
migraine disability
Publications linked to this measurement: 1
Other human research, including observational studies and reviews
- A change was reported before and after use. Its cause cannot be isolated.
Several ingredients were tested together, so this ingredient’s individual effect is unknown.
Patient group · Combination study · Six monthsMeasurement and study conditions
- Study type
- Randomized controlled trial: subjects were randomly assigned to groups for comparison.
- Study population
- Human participants · Patient group
- Ingredients tested
- Ingredient combination
- How results were compared
- Changes within the same group were compared. · Study comparison: Within-treatment migraine-disability change after a vitamin combination; no significant decrease rep
- Additional measurement information
- Secondary outcome
- Measurement time
- Six months
Representative outcome and study details
Human studies reported no clear between-group difference in breast pain severity.
Single-ingredient studies · Human studies · Includes patient groups · between-group comparison
1 publications linked to this result
- Route, form, dose, or population details are incomplete, so the findings cannot be confirmed as directly comparable.
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: C
The 14.9 evidence score includes 1 independent human studies and 1 clinical studies in the representative benefit area. The C tier remains conservative because of limited repetition across independent human clinical studies, too few clinical findings with an explicit effect direction.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 90
Papers linked to this topic 3 · distinct papers 3 · papers with a confirmed human comparison 2 · papers needing additional review 0
A publication may appear in more than one count. These numbers should not be added. Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
- breast pain severity: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1
- frequency of headache attacks: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1
- migraine disability: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
What the research found
breast pain severity
No clear difference in this measurement was found between the compared groups.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
migraine disability
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
frequency of headache attacks
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
No reviewed caution rules are available yet. Reported caution findings are shown below.
Review 1 combination findings and 0 findings that outperformed an ingredient alone.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Cautions reported with another supplement or medication
These studies reported worsening outcomes, reduced absorption, or other cautions with combined use. They do not predict an individual's outcome.
IsoniazidInteractions with medications like isoniazid are mentioned as a cause of Vitamin B6 deficiency.
AntiepilepticsInteractions with certain antiepileptics are mentioned as a cause of Vitamin B6 deficiency.
Reported improvements with combinations
Combination findings are grouped by how the study compared them. This is not a recommendation to combine ingredients.
Combinations with reported improvement
The combination showed improvement, but each ingredient's contribution is unclear.
마그네슘In subjects with severe/extremely severe stress, the combination of magnesium and vitamin B6 resulted in a 24% greater improvement compared to magnesium alone (p=0.0203).