High-dose B vitamin supplementation significantly reduces progression of early-stage subclinical atherosclerosis (carotid artery intima media thickness) in well-nourished healthy B vitamin “replete” individuals at low risk for cardiovascular disease with a fas
Vitamin B6
Condition-specific health context in a specific context is closer to a research marker, so it should be read separately from a directly felt benefit.
Representative tier calculated from paper evidence that passed the collection audit.
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Condition-specific evidence2 studiesTier-CCondition-specific health context in a specific contextFairly consistent positive signal in studiesResearch marker focusSupplement contextThis result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Nutrient status2 studiesTier-CNutrient status markersSome positive signal observedResearch marker focusSupplement contextThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Glucose and metabolic health1 studiesTier-CGlucose and metabolic health markersSignal is still limitedResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Recent research
10 new papers were added in this period. No new risk signal was identified.
What's new
Most notable recent finding
Study dosage range (reference only)
Key cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Standalone side effects
Combinations studied together
The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins, and is associated with a lower final cognitive test scores.
These randomized trial data from a large cohort of women at high risk of CVD indicate that daily supplementation with folic acid/B6/B12 may reduce the risk of age-related macular degeneration.
3 more summariesLimited representative sample by study type.>
Preliminary evidence is provided for the efficacy of high-dose B-group supplementation in reducing oxidative stress and inflammation through increasing oxidative metabolism, which may also promote myelination, cellular metabolism, and energy storage.
This first randomized trial evaluating the effects of combined magnesium and vitamin B6 supplementation on stress in a stressed population with low magnesemia using a validated measure of perceived stress suggests oral Mg supplementation alleviated stress in h
In healthy adults, two-hour PM2.5 exposure substantially increases HR, reduces HRV, and increases WBC, which is reduced by B vitamin supplementation.