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Tier-CPublic-ready6/11/2026

Vitamin B6

Condition-specific health context in a specific context is closer to a research marker, so it should be read separately from a directly felt benefit.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
0.0
Condition-specific health context in a specific contextNutrient status markersGlucose and metabolic health markers

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Condition-specific evidence
2 studiesTier-C
Condition-specific health context in a specific context
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Condition-specific health context
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status
2 studiesTier-C
Nutrient status markers
Some positive signal observedResearch marker focusSupplement context
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.3
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Glucose and metabolic health
1 studiesTier-C
Glucose and metabolic health markers
Signal is still limitedResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
8.5
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
observational
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Study dosage range (reference only)

Lower dose
30
mg/day
Higher dose
30
mg/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
1.5
Caution band: Low
Caution signals
1
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
1 combo signals and 0 added-signal combos shown below.
Standalone side effects, combination cautions, and positive combos are separated below.

Standalone side effects

Peripheral neuropathy adverse reactions1 papers
Reported adverse reactions related to polyneuropathy and vitamin B6 supplements were analyzed, showing individual differences concerning dose and plasma levels in reported complaints.human · observational

Combinations studied together

The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.

+MagnesiumThe combination of magnesium and vitamin B6 provided additional benefit over magnesium alone in the severe stress subgroup.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 132
observational

High-dose B vitamin supplementation significantly reduces progression of early-stage subclinical atherosclerosis (carotid artery intima media thickness) in well-nourished healthy B vitamin “replete” individuals at low risk for cardiovascular disease with a fas

Key Evidence #2
Public scholarly dataCitation signal: 785
observational

The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins, and is associated with a lower final cognitive test scores.

Key Evidence #3
Public scholarly dataCitation signal: 173
observational

These randomized trial data from a large cohort of women at high risk of CVD indicate that daily supplementation with folic acid/B6/B12 may reduce the risk of age-related macular degeneration.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 85
observational

Preliminary evidence is provided for the efficacy of high-dose B-group supplementation in reducing oxidative stress and inflammation through increasing oxidative metabolism, which may also promote myelination, cellular metabolism, and energy storage.

Public scholarly dataCitation signal: 65
observational

This first randomized trial evaluating the effects of combined magnesium and vitamin B6 supplementation on stress in a stressed population with low magnesemia using a validated measure of perceived stress suggests oral Mg supplementation alleviated stress in h

Public scholarly dataCitation signal: 43
observational

In healthy adults, two-hour PM2.5 exposure substantially increases HR, reduces HRV, and increases WBC, which is reduced by B vitamin supplementation.

Vitamin B6
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