biotech
Bio-AnalystSupplement research
person
arrow_backExplore/Omega-3

Omega-3

Selected research topic

Bone, joint, and mobility

The confirmed comparison studies tested several ingredients together. They cannot isolate the effect of this ingredient.

Some findings concern patients or people with a deficiency.

Publications for this topic
5
Human comparison publications
2
Publications needing review
0

Findings in the studies

  • knee pain

    • No clear difference from the comparison group was found.

      Several ingredients were tested together, so this ingredient’s individual effect is unknown.

      Patient group · Combination study · 24 weeks
      Measurement and study conditions
      Study type
      Randomized controlled trial: subjects were randomly assigned to groups for comparison.
      Study population
      Human participants · Patient group
      Ingredients tested
      Ingredient combination
      How results were compared
      Results were compared between groups. · Study comparison: krill oil versus matching placebo for knee pain over 24 weeks
      Additional measurement information
      Primary outcome
      Measurement time
      24 weeks

  • Knee pain score

    • A better result than the comparison group was reported.

      Several ingredients were tested together, so this ingredient’s individual effect is unknown.

      Patient group · Combination study · Six months
      Measurement and study conditions
      Study type
      Randomized controlled trial: subjects were randomly assigned to groups for comparison.
      Study population
      Human participants · Patient group
      Ingredients tested
      Ingredient combination
      How results were compared
      Results were compared between groups. · Study comparison: Krill oil (EPA, DHA, astaxanthin) versus mixed vegetable oil placebo
      Additional measurement information
      Primary outcome
      Measurement time
      Six months

  • all OA

    Other human research, including observational studies and reviews
    • An association was observed. This does not establish that the ingredient caused the change.

      Several ingredients were tested together, so this ingredient’s individual effect is unknown.

      General population · Combination study · Median follow-up 10.90 years
      Measurement and study conditions
      Study type
      Observational study
      Study population
      Human participants · General population
      Ingredients tested
      Ingredient combination
      How results were compared
      Comparison unclear · Study comparison: Adjusted observational association between questionnaire-reported fish-oil use and incident osteoart
      Additional measurement information
      Primary outcome
      Measurement time
      Median follow-up 10.90 years

  • Joint pain score

    Research with unclear study subject or type
    • The study reported improvement in this measurement.

      Several ingredients were tested together, so this ingredient’s individual effect is unknown.

      What the comparison group used was not confirmed.

      Combination study
      Measurement and study conditions
      Study type
      Randomized controlled trial: subjects were randomly assigned to groups for comparison.
      Study population
      Recorded population category: Patient group. Whether the research involved humans needs confirmation.
      Ingredients tested
      Ingredient combination
      How results were compared
      Results were compared between groups.
      Measurement time
      Not confirmed.
Other measured outcomes (1)

  • knee extensor maximal torque

    Research with unclear study subject or type
    • The study reported improvement in this measurement.

      Several ingredients were tested together, so this ingredient’s individual effect is unknown.

      What the comparison group used was not confirmed.

      Combination study
      Measurement and study conditions
      Study type
      Randomized controlled trial: subjects were randomly assigned to groups for comparison.
      Study population
      Study subject not identified
      Ingredients tested
      Ingredient combination
      How results were compared
      Results were compared between groups.
      Measurement time
      Not confirmed.
Representative outcome and study details

Human studies reported an association with all OA.

combination-ingredient studies · Individual ingredient effects cannot be separated · Human studies · comparator not confirmed

1 publications linked to this result

  • Route, form, dose, or population details are incomplete, so the findings cannot be confirmed as directly comparable.
  • Combination, formula, or class studies do not isolate this ingredient or establish synergy.
Data coverage and detailed study classifications

Paper counts are separated by research topic below. One paper may contribute to multiple findings.

Analysis status: Public-ready

Ingredient analysis date:

How the grade was determined: C

The 50.0 evidence score includes 1 independent human studies and 1 clinical studies in the representative benefit area. The C tier remains conservative because of the evidence centers on contextual or measured outcomes rather than general-use effects, limited repetition across independent human clinical studies.

The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.

Papers linked to this ingredient overall: 115

Papers linked to this topic 5 · distinct papers 5 · papers with a confirmed human comparison 2 · papers needing additional review 0

A publication may appear in more than one count. These numbers should not be added. Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.

  • all OA: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • Joint pain score: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • knee extensor maximal torque: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • knee pain: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1
  • Knee pain score: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1

What the research found

knee pain

No clear difference in this measurement was found between the compared groups.

Controlled study in people · Ingredient combination · Patient group

Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.

Between-group comparison

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

Joint pain score

The study reported improvement in this measurement.

Controlled human study · Ingredient combination · Patient group

Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.

Between-group comparison

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

knee extensor maximal torque

The study reported improvement in this measurement.

Controlled human study · Ingredient combination · Unspecified population

Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.

Between-group comparison

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

Knee pain score

The study reported improvement in this measurement.

Controlled study in people · Ingredient combination · Patient group

Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.

Between-group comparison

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

all OA

An association was observed. This does not establish that the ingredient caused the change.

Observational study · Ingredient combination · General population

Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.

The comparison could not be confirmed.

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

How to read research findings

How should I read research findings?

Research guides

Side effects and combination findings

Findings from this ingredient alone are shown separately from those involving another supplement or medication.

No combination cautions are available to show in the current data. This does not guarantee safety.

Review 2 combination findings and 0 findings that outperformed an ingredient alone.

Reported improvements with combinations

Combination findings are grouped by how the study compared them. This is not a recommendation to combine ingredients.

Combinations with reported improvement

The combination showed improvement, but each ingredient's contribution is unclear.

비타민 DCombined vitamin D and omega-3 fatty acids showed a 31% reduction in autoimmune disease incidence compared to placebo, suggesting a potential additive effect.
알파리포산The combination of omega-3 fatty acids and alpha-lipoic acid showed significant benefits in slowing cognitive and functional decline compared to placebo or omega-3 alone.