biotech

Bio-Analyst

Research Platform
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Tier-BPublic-ready7/4/2026

HMB

Exercise performance and recovery is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
72
Caution signal
Low
Representative score
78.7
Exercise performance and recoveryImmune and respiratory supportGlucose and metabolic health markers

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Exercise performance and recovery
11 studiesTier-A
Exercise performance and recovery
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

Potential benefit studied in Exercise performance and recovery.

Evidence score
81.2
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Immune and respiratory health
1 studiesTier-C
Immune and respiratory support
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Immune and respiratory health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
39.4
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Glucose and metabolic health
1 studiesTier-C
Glucose and metabolic health markers
Some positive signal observedResearch marker focusSupplement context

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.

Evidence score
38.8
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
1.48
g/day
Higher observed study value
3
g/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.3
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
1 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

크레아틴Combined supplementation of HMB and Creatine monohydrate showed a synergistic effect on aerobic power at W8, W4, and WAT compared to the sum of effects from single supplements.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 313
observational

An in depth and objective analysis of HMB research is provided and a comprehensive discussion on possible mechanisms, which HMB may operate through is provided.

Key Evidence #2
Public scholarly dataCitation signal: 249
rct

[Abstract]: Loss of muscle mass due to prolonged bed rest decreases functional capacity and increases hospital morbidity and mortality in older adults. To determine if HMB, a leucine metabolite, is capable of attenuating muscle decline in healthy older adults

Key Evidence #3
Public scholarly dataCitation signal: 118
rct

[Abstract]: This investigation evaluated the effects of oral beta-hydroxy-beta-methylbutyrate (HMB) supplementation on training responses in resistance-trained male athletes who were randomly administered HMB in standard encapsulation (SH), HMB in time release

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 104
rct

[Abstract]: Studies in young adults have demonstrated that beta-hydroxy-beta-methylbutyrate (HMB) can increase gains in strength and fat-free mass during a progressive resistance-training program. The purpose of this study was to determine whether HMB would si

Public scholarly dataCitation signal: 73
observational

Investigation of the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maximal voluntary contraction found no clear acute or timing effects.

Public scholarly dataCitation signal: 72
systematic-review

[Abstract]: BackgroundBeta-hydroxy-beta-methylbutyrate (HMB) has been shown to be effective and superior to other types of protein supplements to attenuate loss of muscle mass, strength and function, however, its benefits in sarcopenic and frail older people r

HMB
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