Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Collagen
Selected research topic
Bone, joint, and mobility
Some measured outcomes improved in human comparison studies. Read these findings with their populations and conditions.
Some findings concern patients or people with a deficiency.
- Publications for this topic
- 8
- Human comparison publications
- 1
- Publications needing review
- 6
Findings in the studies
Joint pain score
About this measure
WOMAC pain score · A questionnaire score measuring joint pain.
- A better result than the comparison group was reported.Patient group · Single ingredient · 180 days.
Measurement and study conditions
- Study type
- Randomized controlled trial: subjects were randomly assigned to groups for comparison.
- Study population
- Human participants · Patient group
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: Low-molecular-weight collagen peptides versus placebo.
- Additional measurement information
- Primary outcome
- Measurement time
- 180 days.
Joint pain
Research with unclear study subject or type
- A change was reported, but the comparison could not be confirmed.Single ingredient
Measurement and study conditions
- Study type
- Systematic review
- Study population
- Study subject not identified
- Ingredients tested
- Single ingredient
- Measurement time
- Not confirmed.
This result is held for interpretation. That does not mean research found no effect.
Outcome groups needing additional review (3)
- BMD of the spine · Distinct papers needing additional review: 1Evidence criteria check: 1
- bone mass · Distinct papers needing additional review: 1Evidence criteria check: 1
- femoral neck · Distinct papers needing additional review: 1Evidence criteria check: 1
One paper can appear under multiple measured outcomes or review reasons, so these counts should not be added together.
Representative outcome and study details
Studies with an unspecified organism reported a change with no confirmed comparison group in Joint pain.
Single-ingredient studies · Population not specified · comparator not confirmed
1 publications linked to this result
- Route, form, dose, or population details are incomplete, so the findings cannot be confirmed as directly comparable.
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: B
The 60.0 evidence score includes 3 independent human studies and 2 clinical studies in the representative benefit area. The B tier remains conservative because of limited repetition across independent human clinical studies, too few clinical findings with an explicit effect direction.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 105
Papers linked to this topic 8 · distinct papers 8 · papers with a confirmed human comparison 1 · papers needing additional review 6
A publication may appear in more than one count. These numbers should not be added. Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
- BMD of the spine: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- bone mass: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- femoral neck: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- Joint pain: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- Joint pain score (WOMAC pain score · A questionnaire score measuring joint pain.): Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1
What the research found
WOMAC pain
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Joint pain
A change was reported, but the comparison could not be confirmed.
Review · Single ingredient · Unspecified population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
BMD of the spine
The study needs further checking before its result can be interpreted.
Controlled study in people · Unknown intervention · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
bone mass
The study needs further checking before its result can be interpreted.
Animal study · indirect · Separable contribution · Unspecified population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
femoral neck
The study needs further checking before its result can be interpreted.
Controlled study in people · Unknown intervention · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Review · Ingredient combination · Unspecified population
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
2 papers · 2 measured outcomes
2 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
No combination cautions are available to show in the current data. This does not guarantee safety.
Side effects and combination studies
No side-effect or combination findings are available to show from the collected papers. This does not establish safety.