Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Coenzyme Q10
Selected research topic
Blood lipids
Some measured outcomes improved in human comparison studies. Read these findings with their populations and conditions.
Some findings concern patients or people with a deficiency.
- Publications for this topic
- 4
- Human comparison publications
- 1
- Publications needing review
- 0
Findings in the studies
HDL-mediated CEC
- A better result than the comparison group was reported.Patient group · Single ingredient · 24 weeks
Measurement and study conditions
- Study type
- Randomized controlled trial: subjects were randomly assigned to groups for comparison.
- Study population
- Human participants · Patient group
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: CoQ10 versus placebo.
- Additional measurement information
- Secondary outcome
- Measurement time
- 24 weeks
TC
Other human research, including observational studies and reviews
- A change was reported, but the comparison could not be confirmed.Patient group · Single ingredient · 12 weeks
Measurement and study conditions
- Study type
- Randomized controlled trial: subjects were randomly assigned to groups for comparison.
- Study population
- Human participants · Patient group
- Ingredients tested
- Single ingredient
- How results were compared
- Study comparison: Coenzyme Q10 200 mg/day versus placebo; post-intervention total cholesterol and LDL-C differences re
- Additional measurement information
- Secondary outcome
- Measurement time
- 12 weeks
HDL-C
Research with unclear study subject or type
- A change was reported, but the comparison could not be confirmed.Single ingredient
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: General population. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Study comparison: Pooled estimates from 50 randomized trials; this abstract does not name trial-level comparator condi
- Measurement time
- Not confirmed.
HDL-cholesterol levels
Research with unclear study subject or type
- The study reported improvement in this measurement.Single ingredient
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: Patient group. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: CoQ10 versus placebo in included trials
- Additional measurement information
- Secondary outcome
- Measurement time
- Not confirmed.
Other measured outcomes (7)
LDL cholesterol
Research with unclear study subject or type
- A change was reported, but the comparison could not be confirmed.Single ingredient
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: General population. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Study comparison: Pooled estimates from 50 randomized trials; this abstract does not name trial-level comparator condi
- Measurement time
- Not confirmed.
LDL-cholesterol
Research with unclear study subject or type
- No clear difference in this measurement was found between the compared groups.Single ingredient
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: Patient group. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: CoQ10 versus placebo in included trials
- Additional measurement information
- Secondary outcome
- Measurement time
- Not confirmed.
lipoprotein (a)
Research with unclear study subject or type
- No clear difference in this measurement was found between the compared groups.Single ingredient
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: Patient group. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: CoQ10 versus placebo in included trials
- Additional measurement information
- Secondary outcome
- Measurement time
- Not confirmed.
total cholesterol
Research with unclear study subject or type
- A change was reported, but the comparison could not be confirmed.Single ingredient
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: General population. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Study comparison: Pooled estimates from 50 randomized trials; this abstract does not name trial-level comparator condi
- Measurement time
- Not confirmed.
total-cholesterol
Research with unclear study subject or type
- The study reported improvement in this measurement.Single ingredient
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: Patient group. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: CoQ10 versus placebo in included trials
- Additional measurement information
- Secondary outcome
- Measurement time
- Not confirmed.
triglycerides
Research with unclear study subject or type
- A change was reported, but the comparison could not be confirmed.Single ingredient
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: General population. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Study comparison: Pooled estimates from 50 randomized trials; this abstract does not name trial-level comparator condi
- Measurement time
- Not confirmed.
triglycerides levels
Research with unclear study subject or type
- No clear difference in this measurement was found between the compared groups.Single ingredient
Measurement and study conditions
- Study type
- Meta-analysis
- Study population
- Recorded population category: Patient group. Whether the research involved humans needs confirmation.
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: CoQ10 versus placebo in included trials
- Additional measurement information
- Secondary outcome
- Measurement time
- Not confirmed.
Representative outcome and study details
Studies with an unspecified organism reported a change with no confirmed comparison group in HDL-C.
Single-ingredient studies · comparator not confirmed
1 publications linked to this result
- Route, form, dose, or population details are incomplete, so the findings cannot be confirmed as directly comparable.
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: B
The 54.4 evidence score includes 1 independent human studies and 1 clinical studies in the representative benefit area. The B tier remains conservative because of limited repetition across independent human clinical studies, too few clinical findings with an explicit effect direction.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 113
Papers linked to this topic 4 · distinct papers 4 · papers with a confirmed human comparison 1 · papers needing additional review 0
A publication may appear in more than one count. These numbers should not be added. Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
- HDL-C: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- HDL-cholesterol levels: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- HDL-mediated CEC: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1
- LDL cholesterol: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- LDL-cholesterol: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- lipoprotein (a): Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- TC: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- total cholesterol: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- total-cholesterol: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- triglycerides: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- triglycerides levels: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
What the research found
HDL-mediated CEC
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HDL-cholesterol levels
The study reported improvement in this measurement.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
LDL-cholesterol
No clear difference in this measurement was found between the compared groups.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
lipoprotein (a)
No clear difference in this measurement was found between the compared groups.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
total-cholesterol
The study reported improvement in this measurement.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
triglycerides levels
No clear difference in this measurement was found between the compared groups.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HDL-C
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
LDL-C
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
TC
A change was reported, but the comparison could not be confirmed.
Controlled study in people · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
total cholesterol
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
triglycerides
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
No combination cautions are available to show in the current data. This does not guarantee safety.
Review 2 combination findings and 0 findings that outperformed an ingredient alone.
Reported improvements with combinations
Combination findings are grouped by how the study compared them. This is not a recommendation to combine ingredients.
Combinations with reported improvement
The combination showed improvement, but each ingredient's contribution is unclear.
CurcuminThe study suggests a possible synergistic effect of nano-curcumin and CoQ10 on clinical features of migraine compared to monotherapy or placebo.
SeleniumCombined supplementation with selenium and Coenzyme Q10 resulted in significantly improved renal function markers compared to placebo.