Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Bacopa
Selected research topic
Digestion and gut health
Some measured outcomes worsened in human comparison studies. The populations and conditions matter.
- Publications for this topic
- 1
- Human comparison publications
- 1
- Publications needing review
- 0
Findings in the studies
digestive complaints
- A worse result than the comparison group was reported.General population · Single ingredient · 12 weeks
Measurement and study conditions
- Study type
- Randomized controlled trial: subjects were randomly assigned to groups for comparison.
- Study population
- Human participants · General population
- Ingredients tested
- Single ingredient
- How results were compared
- Results were compared between groups. · Study comparison: 300 mg/day Bacopa monnieri extract versus placebo
- Additional measurement information
- Secondary outcome
- Measurement time
- 12 weeks
Representative outcome and study details
Human studies reported between-group worsening in digestive complaints.
Single-ingredient studies · Human studies · between-group comparison
1 publications linked to this result
- Route, form, dose, or population details are incomplete, so the findings cannot be confirmed as directly comparable.
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: B
The 60.3 evidence score includes 12 independent human studies and 11 clinical studies in the representative benefit area. The B tier reflects evidence directness, repetition, and consistency together.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 72
Papers linked to this topic 1 · distinct papers 1 · papers with a confirmed human comparison 1 · papers needing additional review 0
A publication may appear in more than one count. These numbers should not be added. Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
- digestive complaints: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1
What the research found
digestive complaints
The study reported worsening in this measurement.
Controlled study in people · Single ingredient · General population
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
No reviewed caution rules are available yet. Reported caution findings are shown below.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Side effects reported with this ingredient alone
Symptoms or adverse events reported in studies without another active ingredient.
Rey Auditory Verbal Learning Test (AVLT)1 papers
In a double-blind, placebo-controlled RCT, 300 mg/day Bacopa monnieri significantly improved verbal learning and memory acquisition in healthy older adults, though gastrointestinal side effects were reported.Human studies · Randomized controlled trial