biotech

Bio-Analyst

Research Platform
person
Tier-BPublic-ready6/11/2026

Riboflavin

Condition-specific health context in a specific context is closer to a research marker, so it should be read separately from a directly felt benefit.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
67.2
Condition-specific health context in a specific contextNutrient status markersStress Response and Sleep Changes

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Condition-specific evidence
3 studiesTier-B
Condition-specific health context in a specific context
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Condition-specific health context
No direct rate reported. Read direction and evidence strength together.
Evidence score
52.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status
2 studiesTier-C
Nutrient status markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Stress and mood
1 studiesTier-C
Stress Response and Sleep Changes
Some positive signal observedFelt benefit focusPatient-group study
These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.
Open metrics
>
Stress and mood balance
No direct rate reported. Read direction and evidence strength together.
Evidence score
32.9
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Blood pressure and vascular health
1 studiesTier-C
Blood pressure and vascular health markers
Some positive signal observedResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Blood pressure and vascular markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
20.8
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Research clues (read separately)

Disease-specific, biomarker, animal, or cell-study findings — not everyday felt benefits.

Specialized clinical context
1 studiesTier-C
Specialized Treatment-Setting Signal
Some positive signal observedDisease markerSpecialized treatment
This evidence comes from contexts such as cancer, mortality, hospitalization, drug combination, or radiation studies. It should not be read as a general supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Fatigue and energy
No direct rate reported. Read direction and evidence strength together.
Evidence score
32.9
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
review
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.4
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
1 combo signals and 0 added-signal combos shown below.
Standalone side effects, combination cautions, and positive combos are separated below.

Combinations studied together

The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.

+MagnesiumA combination supplement containing riboflavin, magnesium, and Q10 showed a trend towards reduced migraine frequency (p=0.23) but significantly reduced migraine pain intensity and disease burden compared to placebo.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 92
review

The importance of riboflavin and its efficient transmembrane transport in human physiology is outlined and recent work with different models of RTD that have revealed possible pathomechanisms contributing to neurodegeneration in patients are focused on.

Key Evidence #2
Public scholarly dataCitation signal: 164
review

The crucial role of riboflavin for general human health, and the clear benefits of rib oflavin treatment in patients with inborn errors of metabolism are described.

Key Evidence #3
Public scholarly dataCitation signal: 156
observational

Treatment with a proprietary nutritional supplement containing magnesium, riboflavin and Q10 had an impact on migraine frequency which showed a trend towards statistical significance and Migraine symptoms and burden of disease were statistically significantly

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 89
observational

The data demonstrate that riboflavin supplementation has a number of anti-inflammatory and anti-oxidant effects in CD, and this is the first study of its kind to demonstrate this.

Public scholarly dataCitation signal: 74
observational

The data show that riboflavin treatment improves complex I activity in the majority of patient-derived fibroblasts tested, and this effect was also reported for most of the treated patients and is mirrored in the survival data.

Public scholarly dataCitation signal: 58
observational

The findings suggest that prolonged exclusive breastfeeding may not provide sufficient B vitamins for small infants, and that this may have a negative effect on early gross motor development.

Riboflavin
arrow_backBack to list