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Tier-BPublic-ready6/12/2026

Plant Sterols

Cholesterol and triglycerides is the main area connected here, and any felt benefit should be read together with the human evidence base.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
59.1
Cholesterol and triglyceridesGlucose and metabolic health markersBlood pressure and vascular health markers

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Blood lipids
3 studiesTier-C
Cholesterol and triglycerides
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Blood lipids.
Open metrics
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Cholesterol and triglycerides
No direct rate reported. Read direction and evidence strength together.
Evidence score
47.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Glucose and metabolic health
2 studiesTier-C
Glucose and metabolic health markers
Some positive signal observedResearch marker focusSupplement context
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.3
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Blood pressure and vascular health
1 studiesTier-C
Blood pressure and vascular health markers
Some positive signal observedResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Blood pressure and vascular markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
22.8
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
observational
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.3
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Side-effect and combination signals

No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 31
observational

The tested nutraceutical association is able to improve the positive effects of a Mediterranean diet on a large number of CV risk factors and consequently of the estimated CV risk.

Key Evidence #2
Public scholarly dataCitation signal: 70
observational

Intrinsic phytosterols at levels present in a healthy diet are biologically active and have large effects on whole-body cholesterol metabolism not reflected in circulating LDL.

Key Evidence #3
Public scholarly dataCitation signal: 60
observational

[Abstract]: BackgroundAs the worldwide dietary pattern becomes more westernized, the metabolic syndrome is reaching epidemic proportions. Lifestyle modifications including diet and exercise are recommended as first-line intervention for treating metabolic synd

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 43
observational

The creams (particularly the LMN) have anti-inflammatory and antioxidant effects in addition to lowering LDL-c, Apo B and ApoB/ApoA ratio and provide new dietary therapeutic perspectives.

Public scholarly dataCitation signal: 40
observational

The association of phytosterol and red yeast rice seems to have additive cholesterol lowering effect, reaching a clinically significant LDL-Cholesterol reduction in mildly hypercholesterolemic patients.

Public scholarly dataCitation signal: 37
observational

Supplementation with phytosterol may be a beneficial adjuvant therapy in hypertensive patients as well as a complementary preventive option in prehypertensive and normotensive individuals, however, this issue is still open and requires further investigation in

Plant Sterols
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