The tested nutraceutical association is able to improve the positive effects of a Mediterranean diet on a large number of CV risk factors and consequently of the estimated CV risk.
Plant Sterols
Cholesterol and triglycerides is the main area connected here, and any felt benefit should be read together with the human evidence base.
Representative tier calculated from paper evidence that passed the collection audit.
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Blood lipids3 studiesTier-CCholesterol and triglyceridesFairly consistent positive signal in studiesFelt benefit focusSupplement contextPotential benefit studied in Blood lipids.Open metrics>
Glucose and metabolic health2 studiesTier-CGlucose and metabolic health markersSome positive signal observedResearch marker focusSupplement contextThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Blood pressure and vascular health1 studiesTier-CBlood pressure and vascular health markersSome positive signal observedResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Recent research
10 new papers were added in this period. No new risk signal was identified.
What's new
Most notable recent finding
Key cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Side-effect and combination signals
No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
Intrinsic phytosterols at levels present in a healthy diet are biologically active and have large effects on whole-body cholesterol metabolism not reflected in circulating LDL.
[Abstract]: BackgroundAs the worldwide dietary pattern becomes more westernized, the metabolic syndrome is reaching epidemic proportions. Lifestyle modifications including diet and exercise are recommended as first-line intervention for treating metabolic synd
3 more summariesLimited representative sample by study type.>
The creams (particularly the LMN) have anti-inflammatory and antioxidant effects in addition to lowering LDL-c, Apo B and ApoB/ApoA ratio and provide new dietary therapeutic perspectives.
The association of phytosterol and red yeast rice seems to have additive cholesterol lowering effect, reaching a clinically significant LDL-Cholesterol reduction in mildly hypercholesterolemic patients.
Supplementation with phytosterol may be a beneficial adjuvant therapy in hypertensive patients as well as a complementary preventive option in prehypertensive and normotensive individuals, however, this issue is still open and requires further investigation in