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Tier-CPublic-ready6/12/2026

Phosphatidylserine

Cognition, memory, and focus is the main area connected here, and any felt benefit should be read together with the human evidence base.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
59.4
Cognition, memory, and focusStress Response and Sleep ChangesBlood pressure and vascular health markers

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Cognition and focus
3 studiesTier-B
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study
Potential benefit studied in Cognition and focus.
Open metrics
>
Cognition, memory, and focus
No direct rate reported. Read direction and evidence strength together.
Evidence score
52.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Stress and mood
2 studiesTier-C
Stress Response and Sleep Changes
Some positive signal observedFelt benefit focusSupplement context
These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.
Open metrics
>
Stress and mood balance
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.3
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Blood pressure and vascular health
1 studiesTier-C
Blood pressure and vascular health markers
Some positive signal observedResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Blood pressure and vascular markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
38.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Men's health
1 studiesTier-C
Male Reproductive Health Markers
Some positive signal observedResearch marker focusSupplement context
These findings come from sperm, semen, or hormone markers such as testosterone, LH, FSH, and inhibin B. They are closer to research measurements than a directly felt benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Male reproductive and hormone markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
34.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Immune and respiratory health
1 studiesTier-C
Immune and respiratory support
Some positive signal observedFelt benefit focusPatient-group study
Potential benefit studied in Immune and respiratory health.
Open metrics
>
Immune and respiratory support
No direct rate reported. Read direction and evidence strength together.
Evidence score
20.9
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
observational
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Study dosage range (reference only)

Lower dose
200
mg/day
Higher dose
400
mg/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.3
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
1 combo signals and 0 added-signal combos shown below.
Standalone side effects, combination cautions, and positive combos are separated below.

Combinations studied together

The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.

+Omega-3Phosphatidylserine combined with omega-3 showed improved efficacy for hyperactivity compared to single agents in the network meta-analysis.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 70
observational

The herein reported results reinforce the potential of this novel immunotherapy to re-establish immunological tolerance, opening the door to new therapeutic approaches in the field of autoimmunity.

Key Evidence #2
Public scholarly dataCitation signal: 146
observational

The current understanding of ApoEVs, in particular, the ApoEV subtype called apoptotic bodies (ApoBDs), is examined and a subset of ApoBDs can be larger than 5 μm and smaller than 1 μm based on flow cytometry and live time-lapse microscopy analysis, respective

Key Evidence #3
Public scholarly dataCitation signal: 95
observational

Findings are indicated that DHA supplementation promotes phosphatidylserine accumulation and inhibits neuronal cell death under challenged conditions, supporting a notion that DHA is an important neuroprotective agent.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 83
observational

Short-term supplementation with PS+PA in patients with AD showed a stabilizing effect on daily functioning, emotional state and self-reported general condition, and the data encourage long-term studies with PS +PA in AD patients and other elderly with memory o

Public scholarly dataCitation signal: 77
review

Phosphatidylserine and PS liposome could be a promising supplementation for neurodegenerative and neurodevelopmental diseases.

Public scholarly dataCitation signal: 60
observational

It is demonstrated that soybean-derived phosphatidylserine (SB-PS) may have favorable effects on cognitive function in elderly with memory complaints and suggests that SB-PS is safe for human consumption and may serve as a safe alternative to phosphate extract

Phosphatidylserine
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