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Tier-CPublic-ready6/30/2026

Manganese

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

The 42.1 score includes research signals from patient or disease contexts. General supplement evidence is not repeated enough, so the C tier remains conservative.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
50
Caution signal
Moderate
Context-specific research signal
42.1
Glucose and metabolic health markersDigestion and gut comfortExercise performance and recovery

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
4 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
54.6
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Digestion and gut health
1 studiesTier-C
Digestion and gut comfort
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Digestion and gut health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Exercise performance and recovery
1 studiesTier-C
Exercise performance and recovery
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Exercise performance and recovery. These findings come from a defined study population, so everyday effects may differ.

Evidence score
22.8
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range comes from human studies in general supplement-use contexts.

Lower observed study value
1.46
mg/day
Higher observed study value
3.52
mg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
2.0
Caution band: Moderate
Caution signals
8
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

manganism1 papers
Manganese toxicity manifests as manganism in occupational settings and increasingly in environmental exposures including contaminated foods and water.Human studies · Systematic review
Oxidative stress1 papers
The review highlights evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity, identifying molecular targets involved in mitochondrial dysfunction, inflammation, and cytotoxicity.Cell studies · Systematic review
Mitochondrial dysfunction1 papers
Studies identified molecular targets of manganese toxicity playing a role in mitochondrial dysfunction.Cell studies · Systematic review
Manganese-induced neurotoxicity1 papers
Systematic reviews found insufficient data to establish a dose-response relationship for manganese-induced neurotoxicity, but a safe level of intake of 8 mg/day for adults and 2-7 mg/day for other groups was derived from background dietary intakes.Human studies · Systematic review
Inflammation1 papers
The review notes that manganese exposure triggers cellular responses involving inflammation.Cell studies · Systematic review
Developmental Neurotoxicity1 papers
Manganese is identified as an additional developmental neurotoxicant based on epidemiological studies documenting its role in injuring the developing brain.Human studies · Systematic review
Cytotoxicity1 papers
Manganese exposure is associated with cytotoxicity as part of its neurotoxic pathogenesis.Cell studies · Systematic review
Brain function1 papers
The review states that while manganese is an essential element, higher amounts may be toxic, primarily affecting the brain.Human studies · Systematic review

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 1585
review

To control the pandemic of developmental neurotoxicity, a global prevention strategy is proposed and chemicals in existing use and all new chemicals must therefore be tested for developmental neurotoxicity is proposed.

Key Evidence #2
Public scholarly dataCitation signal: 715
review

This report provides a comprehensive review on new knowledge gained in the Mn research field and suggests that beyond traditionally recognized occupational manganism, Mn exposures and the ensuing toxicities occur in a variety of environmental settings, nutriti

Key Evidence #3
Public scholarly dataCitation signal: 185
review

The current knowledge of the MnSOD enzymatic mechanism and ongoing studies into solving the remaining mysteries are reviewed, focusing on human MnS OD, the most significant enzyme in protecting against ROS in the human body.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 178
observational

The emerging evidence suggests that working memory is significantly affected by chronic Mn exposure and this may be mediated by alterations in brain structures associated with the working memory network including the caudate nucleus in the striatum, frontal co

Public scholarly dataCitation signal: 173
review

The current understanding of how dietary metals modulate host-microbe interactions and the subsequent impact on the outcome of disease is described.

Public scholarly dataCitation signal: 160
observational

The area can be categorized as a high-risk zone for iron and manganese-related problems and needs special attention in order to protect public health of local residents.

Manganese
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