biotech

Bio-Analyst

Research Platform
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Tier-BPublic-ready7/5/2026

L-Theanine

Cognition, memory, and focus is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
97
Caution signal
Low
Representative score
50.0
Cognition, memory, and focusStress Response and Sleep ChangesBlood pressure and vascular markers

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Cognition and focus
4 studiesTier-B
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

Potential benefit studied in Cognition and focus.

Evidence score
66.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Sleep
1 studiesTier-C
Stress Response and Sleep Changes
Some positive signal observedFelt benefit focusSupplement context

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
44.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood pressure and vascular health
1 studies
Blood pressure and vascular markers
Some positive signal observedFelt benefit focusSupplement context

Research has examined possible effects in the Blood pressure and vascular health area. This does not predict an individual result.

Evidence score
35.9
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
50
mg/day
Higher observed study value
400
mg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.8
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
1 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

CaffeineL-theanine combined with caffeine significantly reduced caffeine-induced tachycardia (17% vs 92%) and state anxiety compared to caffeine alone.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 352
rct

[Abstract]: L-Theanine is an amino acid contained in green tea leaves which is known to block the binding of L-glutamic acid to glutamate receptors in the brain. Because the characteristics of L-Theanine suggest that it may influence psychological and physiolo

Key Evidence #2
Public scholarly dataCitation signal: 246
rct

[Abstract]: L-Theanine is an amino acid found naturally in tea. Despite the common consumption of L-theanine, predominantly in combination with caffeine in the form of tea, only one study to date has examined the cognitive effects of this substance alone, and

Key Evidence #3
Public scholarly dataCitation signal: 162
rct

[Abstract]: Tea is the most widely consumed beverage in the world after water. Tea is known to be a rich source of flavonoid antioxidants. However tea also contains a unique amino acid, L-theanine that may modulate aspects of brain function in humans. Evidence

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 150
observational

Substantial increase in GABA receptor and GluN1 expression is attributed to the potential neuromodulatory properties of GABA/l-theanine combination, which seems to affect sleep behaviour.

Public scholarly dataCitation signal: 143
rct

[Abstract]: L-Theanine (delta-glutamylethylamide) is one of the predominant amino acids ordinarily found in green tea, and historically has been used as a relaxing agent. The current study examined the acute effects of L-theanine in comparison with a standard

Public scholarly dataCitation signal: 132
rct

[Abstract]: This randomized, placebo-controlled, crossover, and double-blind trial aimed to examine the possible effects of four weeks L-theanine administration on stress-related symptoms and cognitive functions in healthy adults. Participants were 30 individu

L-Theanine
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