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Tier-BPublic-ready6/11/2026

Folate

Menstrual and women's health is the main area connected here, and any felt benefit should be read together with the human evidence base.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
62.0
Menstrual and women's healthCondition-specific health context in a specific contextNutrient status markers

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Women's health
7 studiesTier-B
Menstrual and women's health
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study
Potential benefit studied in Women's health.
Open metrics
>
Menstrual and women's health
No direct rate reported. Read direction and evidence strength together.
Evidence score
60.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Condition-specific evidence
2 studiesTier-C
Condition-specific health context in a specific context
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Condition-specific health context
No direct rate reported. Read direction and evidence strength together.
Evidence score
47.4
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status
2 studiesTier-C
Nutrient status markers
Some positive signal observedResearch marker focusSupplement context
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.3
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Glucose and metabolic health
1 studiesTier-C
Glucose and metabolic health markers
Some positive signal observedResearch marker focusSupplement context
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
40.5
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
review
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Study dosage range (reference only)

Lower dose
0.4
mg/day
Higher dose
0.8
mg/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
1.0
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Side-effect and combination signals

No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 657
review

The results of the first comparison, involving 6708 births with information on NTDs and other infant outcomes, show a protective effect of daily folic acid supplementation (alone or in combination with other vitamins and minerals) in preventing N TDs compared

Key Evidence #2
Public scholarly dataCitation signal: 196
observational

In this small trial of children with non-syndromic ASD and language impairment, treatment with high-dose folinic acid for 12 weeks resulted in improvement in verbal communication as compared with placebo, particularly in those participants who were positive fo

Key Evidence #3
Public scholarly dataCitation signal: 101
observational

Folic acid and vitamin B12 supplementation showed a positive therapeutic effect in AD patients who were not on a folic acid-fortified diet, helping to delineate nutrient intervention as far as public health management for the prevention of dementia is concerne

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 95
observational

A number of important barriers and enablers exist for women regarding the delivery and uptake of preconception care and periconceptional folate supplementation and it is essential that these patient perspectives are addressed in both the implementation of evid

Public scholarly dataCitation signal: 85
observational

Preliminary evidence is provided for the efficacy of high-dose B-group supplementation in reducing oxidative stress and inflammation through increasing oxidative metabolism, which may also promote myelination, cellular metabolism, and energy storage.

Public scholarly dataCitation signal: 84
observational

There is high certainty that folic acid supplementation has a substantial net benefit to prevent neural tube defects in their offspring.

Folate
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