A best practice workflow for laboratory scientists to evaluate discrepant immunoassay results is proposed, comprising: serial dilution; retesting after biotin clearance and/or repeat testing on an alternate platform; and confirmation of the presence of biotin
Biotin
Condition-specific health context in a specific context is closer to a research marker, so it should be read separately from a directly felt benefit.
Representative tier calculated from paper evidence that passed the collection audit.
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Condition-specific evidence4 studiesTier-CCondition-specific health context in a specific contextFairly consistent positive signal in studiesResearch marker focusSupplement contextThis result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Glucose and metabolic health1 studiesTier-CGlucose and metabolic health markersSome positive signal observedResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Blood lipids1 studiesTier-CCholesterol and triglyceridesSome positive signal observedFelt benefit focusPatient-group studyPotential benefit studied in Blood lipids.Open metrics>
Recent research
10 new papers were added in this period. No new risk signal was identified.
What's new
Most notable recent finding
Study dosage range (reference only)
Key cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Side-effect and combination signals
No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
A smaller promiscuous biotin ligase for proximity biotinylation called BioID2 enables more-selective targeting of fusion proteins, requires less biotin supplementation, exhibits enhanced labeling of proximate proteins, and demonstrates the use of a flexible li
In a double-blind, placebo-controlled study, MD1003 achieves sustained reversal of MS-related disability in a subset of patients with progressive MS and is well tolerated.
3 more summariesLimited representative sample by study type.>
Four-week probiotic plus biotin supplementation, in inpatient individuals with a major depressive disorder diagnosis, showed an overall beneficial effect of clinical treatment, however, probiotic intervention compared to placebo only differed in microbial dive
This study showed that MD 1003 did not significantly improve disability or walking speed in patients with progressive multiple sclerosis and thus, in addition to the potential of MD1003 for deleterious health consequences from interference of laboratory tests,
The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker analytical results that are discordant with the clinical situation.