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Tier-BPublic-ready6/12/2026

Berberine

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
62.3
Glucose and metabolic health markersNutrient status markersStress Response and Sleep Changes

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
4 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
54.6
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status
2 studiesTier-C
Nutrient status markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Stress and mood
1 studiesTier-C
Stress Response and Sleep Changes
Some positive signal observedFelt benefit focusPatient-group study
These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.
Open metrics
>
Stress and mood balance
No direct rate reported. Read direction and evidence strength together.
Evidence score
20.9
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Blood lipids
1 studiesTier-C
Cholesterol and triglycerides
Signal is still limitedFelt benefit focusPatient-group study
Potential benefit studied in Blood lipids.
Open metrics
>
Cholesterol and triglycerides
No direct rate reported. Read direction and evidence strength together.
Evidence score
11.8
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Digestion and gut health
1 studiesTier-C
Digestion and gut comfort
Signal is still limitedFelt benefit focusPatient-group study
Potential benefit studied in Digestion and gut health.
Open metrics
>
Digestion and gut comfort
No direct rate reported. Read direction and evidence strength together.
Evidence score
11.8
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Immune and respiratory health
2 studiesTier-C
Immune and respiratory support
Signal is still limitedFelt benefit focusPatient-group study
Potential benefit studied in Immune and respiratory health.
Open metrics
>
Immune and respiratory support
No direct rate reported. Read direction and evidence strength together.
Evidence score
5.9
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
observational
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.8
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Side-effect and combination signals

No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 91
observational

This study confirmed that BBR and Prob (B. breve) could exert a synergistic hypolipidemic effect on PL, acting as a gut lipid sink to achieve better lipidemia and CVD risk control in T2D.

Key Evidence #2
Public scholarly dataCitation signal: 220
observational

A deeper understanding of berberine's effectiveness is delves into by integrating network pharmacology and molecular docking techniques in the context of treating inflammatory diseases, providing guidance and reference for berberine's subsequent revelation of

Key Evidence #3
Public scholarly dataCitation signal: 207
observational

Animal experiments showed that BBR located favorably in the liver and altered hepatic metabolism-related gene expression in an animal model of NAFLD treated with BBR, suggesting that the therapeutic effect of BBR may involve a direct regulation of hepatic lipi

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 152
observational

It is shown that BBR supplementation reverts mitochondrial dysfunction induced by High Fat Diet and hyperglycemia in skeletal muscle, in part due to an increase in mitochondrial biogenesis, and an important role for SIRT1 and mitochondrialBiogenesis in the pre

Public scholarly dataCitation signal: 79
review

It is found that berberine can work as an anti-inflammatory and antioxidant, where the state of inflammation and oxidative stress itself has an influence on the condition of diabetes mellitus.

Public scholarly dataCitation signal: 71
observational

Taken together, berberine could alleviate intestinal barrier damage injured by high-fat or high-carbohydrate diet and improve the growth performance of blunt snout bream.

Berberine
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