Key Evidence #1
observationalPublic scholarly dataCitation signal: 172
Vitamin K supplementation for 36 months at doses attainable in the diet may reduce progression of insulin resistance in older men and women.
Tier-BPublic-ready6/11/2026
Vitamin K
Blood pressure and vascular markers is the main area connected here, and any felt benefit should be read together with the human evidence base.
Representative tier calculated from paper evidence that passed the collection audit.
Papers analyzed
20
Caution signal
Low
Representative score
67.3
Blood pressure and vascular markersGlucose and metabolic health markersBone, joint, and mobility
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Blood pressure and vascular health3 studiesTier-BBlood pressure and vascular markersFairly consistent positive signal in studiesFelt benefit focusPatient-group studyPotential benefit studied in Blood pressure and vascular health.Open metrics>
Blood pressure and vascular health
3 studiesTier-B
Blood pressure and vascular markers
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study
Potential benefit studied in Blood pressure and vascular health.
Open metrics
>Blood pressure and vascular markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
52.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Glucose and metabolic health3 studiesTier-CGlucose and metabolic health markersFairly consistent positive signal in studiesResearch marker focusSupplement contextThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Glucose and metabolic health
3 studiesTier-C
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
47.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Bone and joint health3 studiesTier-CBone, joint, and mobilitySome positive signal observedFelt benefit focusSupplement contextPotential benefit studied in Bone and joint health.Open metrics>
Bone and joint health
3 studiesTier-C
Bone, joint, and mobility
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Bone and joint health.
Open metrics
>Bone, joint, and mobility
No direct rate reported. Read direction and evidence strength together.
Evidence score
40.5
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status3 studiesTier-CNutrient status markersSome positive signal observedResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Nutrient status
3 studiesTier-C
Nutrient status markers
Some positive signal observedResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
24.4
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Research clues (read separately)
Disease-specific, biomarker, animal, or cell-study findings — not everyday felt benefits.
Specialized clinical context1 studiesTier-CSpecialized Treatment-Setting SignalSome positive signal observedDisease markerSpecialized treatmentThis evidence comes from contexts such as cancer, mortality, hospitalization, drug combination, or radiation studies. It should not be read as a general supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Specialized clinical context
1 studiesTier-C
Specialized Treatment-Setting Signal
Some positive signal observedDisease markerSpecialized treatment
This evidence comes from contexts such as cancer, mortality, hospitalization, drug combination, or radiation studies. It should not be read as a general supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>Blood pressure and vascular markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
20.9
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Recent research
Updated This Month10 new papers
10 new papers were added in this period. No new risk signal was identified.
What's new
10 new papers were added.No new risk signal was identified.
Most notable recent finding
This is the most meaningful new study in the latest update.
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paperKey cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Caution index
0.0
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.
Side-effect and combination signals
No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
Key Evidence #2
reviewPublic scholarly dataCitation signal: 107
This work aimed to review the existing data on the association between circulating dpucMGP and vascular calcification, renal function, mortality, and cardiovascular disease in distinct populations.
Key Evidence #3
observationalPublic scholarly dataCitation signal: 85
Poor vitamin K status was associated with high concentrations of cytokines involved in bone turnover, but vitamin K supplementation did not confer a decrease in cytokine concentrations.
3 more summariesLimited representative sample by study type.>
Public scholarly dataCitation signal: 77
observationalA systematic review and meta-analysis of the effect of vitamin K supplementation on VS and VC and association of inactive VKDP levels with incident cardiovascular disease and mortality found Vitamin K supplementation significantly reduced VC, but not VS, compa
Public scholarly dataCitation signal: 71
observationalVitamin K deficiency, as assessed by high dp-ucMGP levels, is profound in hemodialysis patients from the Eastern Mediterranean region and it is significantly correlated with vascular calcifications.
Public scholarly dataCitation signal: 71
reviewAlthough current research appoints to a beneficial effect of vitamin K in bone and muscle, further studies overcoming the current limitations are required in order to incorporate this supplementation in the clinical management of patients with osteosarcopenia.
Vitamin K
arrow_backBack to listEvidence score: 67.3|Caution index: 0.0