Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall and patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.
Vitamin D
Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.
Representative tier calculated from paper evidence that passed the collection audit.
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Glucose and metabolic health4 studiesTier-BGlucose and metabolic health markersFairly consistent positive signal in studiesResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Immune and respiratory health3 studiesTier-BImmune and respiratory supportFairly consistent positive signal in studiesFelt benefit focusPatient-group studyPotential benefit studied in Immune and respiratory health.Open metrics>
Condition-specific evidence2 studiesTier-CCondition-specific health context in a specific contextFairly consistent positive signal in studiesResearch marker focusSupplement contextThis result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Digestion and gut health1 studiesTier-CDigestion and gut comfortSome positive signal observedFelt benefit focusSupplement contextPotential benefit studied in Digestion and gut health.Open metrics>
Bone and joint health2 studiesTier-CBone, joint, and mobilitySome positive signal observedFelt benefit focusSupplement contextPotential benefit studied in Bone and joint health.Open metrics>
Research clues (read separately)
Disease-specific, biomarker, animal, or cell-study findings — not everyday felt benefits.
Specialized clinical context1 studiesTier-CSpecialized Treatment-Setting SignalSome positive signal observedDisease markerSpecialized treatmentThis evidence comes from contexts such as cancer, mortality, hospitalization, drug combination, or radiation studies. It should not be read as a general supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Recent research
10 new papers were added in this period. No new risk signal was identified.
What's new
Most notable recent finding
Study dosage range (reference only)
Key cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Side-effect and combination signals
No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
This study shows proof-of-principle that specific nutritional supplementation alone might benefit geriatric patients, especially relevant for those who are unable to exercise.
Among persons at high risk for type 2 diabetes not selected for vitamin D insufficiency, vitamin D3 supplementation at a dose of 4000 IU per day did not result in a significantly lower risk of diabetes than placebo.
3 more summariesLimited representative sample by study type.>
It is suggested that vitamin D supplementation does not prevent fractures or falls, or have clinically meaningful effects on bone mineral density, and there is little justification to use vitamin D supplements to maintain or improve musculoskeletal health.
The findings suggest that vitamin D supplementation does not confer cardiovascular protection and is not indicated for this purpose.
Vitamin D supplementation for five years, with or without omega 3 fatty acids, reduced autoimmune disease by 22%, while omega3 fatty acid supplementation with or with vitamin D reduced the autoimmune disease rate by 15% (not statistically significant).