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Public-ready6/28/2026

Vitamin D

Papers analyzed
126
Immune and respiratory supportGlucose and metabolic health markersExercise performance and recovery
What to look for in this research

Immune and respiratory support is the main area connected here, and any felt benefit should be read together with the human evidence base.

Main benefit evidence

Review human evidence by goal.

Immune and respiratory health
Immune and respiratory support
Measured outcomes: Immune and respiratory support

Potential benefit studied in Immune and respiratory health.

Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

4 human studies in a specific clinical context are available separately.

Check this goal in more detail
Glucose and metabolic health
Glucose and metabolic health markers
Measured outcomes: Glucose and metabolic markers

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

1 human studies in a specific clinical context are available separately.

Check this goal in more detail
Exercise performance and recovery
Exercise performance and recovery
Measured outcomes: Exercise performance and recovery

Potential benefit studied in Exercise performance and recovery. These findings come from a defined study population, so everyday effects may differ.

Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

Check this goal in more detail
Stress and mood
Stress Response and Sleep Changes
Measured outcomes: Stress and mood balance

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

1 human studies in a specific clinical context are available separately.

Check this goal in more detail
Nutrient status and deficiency
Blood-Level or Deficiency Marker
Measured outcomes: Blood level or deficiency correction markers

This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.

Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

Check this goal in more detail

What does a research result actually tell you?

Reading research

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution signals
3
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
3 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

renal failure, cardiac arrhythmia, status epilepticus1 papers
Chronic and high-dose vitamin D therapy can lead to life-threatening complications including renal failure, cardiac arrhythmia, and status epilepticus.Human studies · Meta-analysis
Adverse reactions (hypercalciuria, hypervitaminosis D, kidney stones, gastrointestinal symptoms, mild itch)1 papers
Six studies reported adverse reactions potentially attributable to vitamin D, including hypercalciuria, hypervitaminosis D, kidney stones, gastrointestinal symptoms, and mild itch, occurring across both treatment and control arms.Human studies · Meta-analysis
Adverse effect signal1 papers
The review mentions that vitamin D toxicity may manifest as fatigue, muscle weakness, or urinary dysfunction.Human studies · Study type not identified

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

오메가-3Combined vitamin D and omega-3 fatty acids showed a 31% reduction in autoimmune disease incidence compared to placebo, suggesting a potential additive effect.
BCAACombination with Vitamin D significantly improved appendicular skeletal muscle mass/height2 compared to control.
마그네슘Co-supplementation with Vitamin D and Magnesium resulted in significant improvements in behavioral function and mental health scores compared to placebo.
Vitamin D
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