New evidence for both prevalence and absolute burden of vitamin A deficiency should be used to reconsider, and possibly revise, the list of priority countries for high-dose vitamin A supplementation such that a country's priority status takes into account both
Vitamin A
Menstrual and women's health is the main area connected here, and any felt benefit should be read together with the human evidence base.
Representative tier calculated from paper evidence that passed the collection audit.
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Women's health1 studiesTier-CMenstrual and women's healthSome positive signal observedFelt benefit focusPatient-group studyPotential benefit studied in Women's health.Open metrics>
Nutrient status1 studiesTier-CNutrient status markersSome positive signal observedResearch marker focusSupplement contextThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Specialized clinical context2 studiesTier-CSpecialized Treatment-Setting SignalSome positive signal observedDisease markerSupplement contextThis evidence comes from contexts such as cancer, mortality, hospitalization, drug combination, or radiation studies. It should not be read as a general supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Condition-specific evidence2 studiesTier-CCondition-specific health context in a specific contextSome positive signal observedResearch marker focusSupplement contextThis result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Recent research
10 new papers were added in this period. No new risk signal was identified.
What's new
Most notable recent finding
Key cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Side-effect and combination signals
No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
This work examined data from 82 countries implementing VAS programs, identified other VA programs, and assessed the recentness of national VA deficiency (VAD) data, and identified three countries that have scaled down VAS, but given the lack of VA deficiency d
β-Carotene from maize was efficacious when consumed as a staple food in this population and could avoid the potential for hypervitaminosis A that was observed with the use of preformed VA from supplementation and fortification.
3 more summariesLimited representative sample by study type.>
Beta-carotene and vitamin E in doses higher than the RDA seem to significantly increase mortality, whereas the authors lack information on vitamin A.
An extensive review of the literature was conducted to identify conflicting or incomplete data on the topic as well as any gaps in existing data, and recommend routine prenatal vitamin A supplementation for the prevention of maternal and infant morbidity and m
A systematic review of published randomized controlled trials (RCTs) and quasi-experimental (QE) studies found that vaccination was effective in preventing measles disease and vitamin A treatment found no significant reduction in measles morality.