Key Evidence #1
reviewPublic scholarly dataCitation signal: 573
The pooled data suggest that omega-3 PUFA supplementation may decrease liver fat, however, the optimal dose is currently not known.
Tier-BPublic-ready6/12/2026
Omega-3
Condition-specific health context in a specific context is closer to a research marker, so it should be read separately from a directly felt benefit.
Representative tier calculated from paper evidence that passed the collection audit.
Papers analyzed
20
Caution signal
Low
Representative score
66.4
Condition-specific health context in a specific contextCognition, memory, and focusGlucose and metabolic health markers
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Condition-specific evidence5 studiesTier-BCondition-specific health context in a specific contextFairly consistent positive signal in studiesResearch marker focusSupplement contextThis result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Condition-specific evidence
5 studiesTier-B
Condition-specific health context in a specific context
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>Condition-specific health context
No direct rate reported. Read direction and evidence strength together.
Evidence score
56.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Cognition and focus4 studiesTier-BCognition, memory, and focusFairly consistent positive signal in studiesFelt benefit focusPatient-group studyPotential benefit studied in Cognition and focus.Open metrics>
Cognition and focus
4 studiesTier-B
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study
Potential benefit studied in Cognition and focus.
Open metrics
>Cognition, memory, and focus
No direct rate reported. Read direction and evidence strength together.
Evidence score
54.6
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Glucose and metabolic health4 studiesTier-BGlucose and metabolic health markersFairly consistent positive signal in studiesResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Glucose and metabolic health
4 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
54.6
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Blood lipids2 studiesTier-CCholesterol and triglyceridesFairly consistent positive signal in studiesFelt benefit focusPatient-group studyPotential benefit studied in Blood lipids.Open metrics>
Blood lipids
2 studiesTier-C
Cholesterol and triglycerides
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study
Potential benefit studied in Blood lipids.
Open metrics
>Cholesterol and triglycerides
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status1 studiesTier-CNutrient status markersSome positive signal observedResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Nutrient status
1 studiesTier-C
Nutrient status markers
Some positive signal observedResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Stress and mood1 studiesTier-CStress Response and Sleep ChangesSome positive signal observedFelt benefit focusSupplement contextThese findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.Open metrics>
Stress and mood
1 studiesTier-C
Stress Response and Sleep Changes
Some positive signal observedFelt benefit focusSupplement context
These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.
Open metrics
>Stress and mood balance
No direct rate reported. Read direction and evidence strength together.
Evidence score
40.5
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Recent research
Updated This Month10 new papers
10 new papers were added in this period. No new risk signal was identified.
What's new
10 new papers were added.No new risk signal was identified.
Most notable recent finding
This is the most meaningful new study in the latest update.
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paperKey cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Caution index
0.8
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.
Side-effect and combination signals
No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
Key Evidence #2
reviewPublic scholarly dataCitation signal: 525
The cumulative evidence from RCTs designed to assess the effect of omega-3 polyunsaturated fatty acid supplementation on clinical cardiovascular events is reviewed and prior recommendations for patients with prevalent coronary heart disease are updated.
Key Evidence #3
observationalPublic scholarly dataCitation signal: 283
Treating adults without major comorbidities aged 70 years or older with vitamin D, omega-3s, or a strength-training exercise program did not result in statistically significant differences in improvement in systolic or diastolic blood pressure, nonvertebral fr
3 more summariesLimited representative sample by study type.>
Public scholarly dataCitation signal: 171
review[Abstract]: Omega-3 fatty acids (omega-3 FAs) supplementation effects on oxidants and antioxidant are always controversial. Oxidative stress (OS) is one of the major mechanisms that contribute to the pathogenesis of several chronic diseases. The present system
Public scholarly dataCitation signal: 117
observationalModerate-to-high level of evidence suggested that dietary intake of omega-3 fatty acids could lower the risk of all-cause dementia or cognitive decline by ∼20% , especially for DHA intake and elevated levels of plasma EPA.
Public scholarly dataCitation signal: 116
observationalResults are the first to report improvements in caregiver behavior in caregiver behavior as a part-mechanism for the efficacy of omega-3, and provide initial evidence that omega-3 supplementation can produce sustained reductions in externalizing and internaliz
Omega-3
arrow_backBack to listEvidence score: 66.4|Caution index: 0.8