biotech
Bio-AnalystResearch Platform
person
Public-ready6/29/2026

Niacin

Papers analyzed
59
Cholesterol and triglyceridesPain, headache, and migraineBlood pressure and vascular health markers
What to look for in this research

Cholesterol and triglycerides is the main area connected here, and any felt benefit should be read together with the human evidence base.

Main benefit evidence

Review human evidence by goal.

Blood lipids
Cholesterol and triglycerides
Measured outcomes: Cholesterol and triglycerides

Potential benefit studied in Blood lipids. These findings come from a defined study population, so everyday effects may differ.

Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

Check this goal in more detail
Pain and headache
Pain, headache, and migraine
Measured outcomes: Pain, headache, and migraine

Potential benefit studied in Pain and headache. These findings come from a defined study population, so everyday effects may differ.

Goal tierNot rated yet

The currently linked research coverage is not broad enough to characterize this goal yet.

Check this goal in more detail
Blood pressure and vascular health
Blood pressure and vascular health markers
Measured outcomes: Blood pressure and vascular markers

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Goal tierNot rated yet

The currently linked research coverage is not broad enough to characterize this goal yet.

Check this goal in more detail
Cardiovascular outcomes
Heart and cardiovascular outcomes
Measured outcomes: Heart and cardiovascular outcomes

Potential benefit studied in Cardiovascular outcomes. These findings come from a defined study population, so everyday effects may differ.

Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

Check this goal in more detail
Stress and mood
Stress Response and Sleep Changes
Measured outcomes: Stress and mood balance

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Goal tierNot rated yet

The currently linked research coverage is not broad enough to characterize this goal yet.

Check this goal in more detail
Cognition and focus
Cognition, memory, and focus
Measured outcomes: Cognition, memory, and focus

Potential benefit studied in Cognition and focus. These findings come from a defined study population, so everyday effects may differ.

Goal tierNot rated yet

The currently linked research coverage is not broad enough to characterize this goal yet.

Check this goal in more detail

What does a research result actually tell you?

Reading research

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution signals
6
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Liver toxicity from high-dose nicotinic acid1 papers
Long-term use of high doses (≥3000 mg/day) of nicotinic acid as a cholesterol-lowering drug can be toxic to the liver.Human studies · Study type not identified
Side effects1 papers
The clinical use of niacin to treat dyslipidemic conditions is limited by its side effects.Human studies · Study type not identified
Cutaneous vasodilation (flushing)1 papers
Nicotinic acid causes a strong side effect of cutaneous vasodilation (flushing) when used to treat dyslipidemias.Human studies · Study type not identified
Gastrointestinal upset1 papers
A single 500 mg dose of immediate-release niacin caused significant gastrointestinal upset in 30% of healthy volunteers compared to 3% in the placebo group (P = .005), with some participants requiring medical attention.Human studies · Randomized controlled trial
Flushing and stomach irritation from nicotinic acid1 papers
Flushing and stomach irritation are main side effects of moderately high supplemental intake of nicotinic acid (>35 mg/day).Human studies · Study type not identified

Caution signals when used with another supplement or medication

These studies reported a negative change, reduced absorption, or another caution when substances were used together. They do not predict an individual outcome.

스타틴Increased risk of all-cause mortality observed when niacin is combined with statins.