biotech

Bio-Analyst

Research Platform
person
arrow_backExplore/Lion's Mane
Tier-CPublic-ready7/6/2026

Lion's Mane

Cognition, memory, and focus is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
90
Caution signal
Low
Representative score
27.5
Cognition, memory, and focusExercise performance and recoveryImmune and respiratory support

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Cognition and focus
2 studiesTier-C
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Cognition and focus. These findings come from a defined study population, so everyday effects may differ.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Exercise performance and recovery
1 studiesTier-C
Exercise performance and recovery
Some positive signal observedFelt benefit focusSupplement context

Potential benefit studied in Exercise performance and recovery.

Evidence score
44.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Immune and respiratory health
1 studiesTier-C
Immune and respiratory support
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Immune and respiratory health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
20.9
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood
1 studiesTier-C
Stress Response and Sleep Changes
Signal is still limitedFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
11.8
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range comes from human studies in general supplement-use contexts.

Lower observed study value
1.8
g/day
Higher observed study value
10
g/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.3
Caution band: Low
Caution signals
2
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Stomach discomfort, headache, and allergic reactions1 papers
The review notes potential side effects of Hericium erinaceus include stomach discomfort, headache, and allergic reactions, though these are commonly unreported.Human studies · Systematic review
gastrointestinal disturbance1 papers
Clinical studies indicate that Hericium erinaceus is generally well tolerated, with gastrointestinal disturbance identified as the most common adverse effect.Human studies · Systematic review

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 295
review

[Abstract]: The culinary and medicinal mushroom Hericium erinaceus is widely consumed in Asian countries, but apparently not in the United States, for its nutritional and health benefits. To stimulate broader interest in the reported beneficial properties, thi

Key Evidence #2
Public scholarly dataCitation signal: 232
rct

[Abstract]: A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake (Hericium erinaceu

Key Evidence #3
Public scholarly dataCitation signal: 114
review

This article critically reviews the current literature on the potential benefits of H. erinaceus as a treatment for depressive disorder as well as its mechanisms underlying the antidepressant-like activities.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 114
review

[Abstract]: Hericium erinaceus, an ideal culinary-medicinal mushroom, has become a well-established candidate in promoting positive brain and nerve health-related activities by inducing the nerve growth factor from its bioactive ingredient. Among its active co

Public scholarly dataCitation signal: 111
rct

[Abstract]: Hericium erinaceus, a well known edible mushroom, has numerous biological activities. Especially hericenones and erinacines isolated from its fruiting body stimulate nerve growth factor (NGF) synthesis, which expects H. erinaceus to have some effec

Public scholarly dataCitation signal: 86
observational

[Abstract]: EP-1 is a polysaccharide with a molecular weight of approximately 3100 Da, which is extracted from the cultured mycelium of Hericium erinaceus. Its anti-ulcerative colitis activity was evaluated in experimental systems using rats with ulcerative co

Lion's Mane
arrow_backBack to list