Key Evidence #1
observationalPublic scholarly dataCitation signal: 421
The results do not support use of oral iron supplementation in patients with HFrEF and iron deficiency, and high-dose oral iron did not improve exercise capacity over 16 weeks.
Tier-BPublic-ready6/11/2026
Iron
Cognition, memory, and focus is the main area connected here, and any felt benefit should be read together with the human evidence base.
Representative tier calculated from paper evidence that passed the collection audit.
Papers analyzed
20
Caution signal
Low
Representative score
61.2
Cognition, memory, and focusNutrient status markersCondition-specific health context in a specific context
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Cognition and focus2 studiesTier-BCognition, memory, and focusFairly consistent positive signal in studiesFelt benefit focusSupplement contextPotential benefit studied in Cognition and focus.Open metrics>
Cognition and focus
2 studiesTier-B
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Cognition and focus.
Open metrics
>Cognition, memory, and focus
No direct rate reported. Read direction and evidence strength together.
Evidence score
58.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status4 studiesTier-CNutrient status markersFairly consistent positive signal in studiesResearch marker focusSupplement contextThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Nutrient status
4 studiesTier-C
Nutrient status markers
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
49.1
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Condition-specific evidence2 studiesTier-CCondition-specific health context in a specific contextFairly consistent positive signal in studiesResearch marker focusSupplement contextThis result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Condition-specific evidence
2 studiesTier-C
Condition-specific health context in a specific context
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>Condition-specific health context
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Blood pressure and vascular health1 studiesTier-CBlood pressure and vascular health markersSome positive signal observedResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Blood pressure and vascular health
1 studiesTier-C
Blood pressure and vascular health markers
Some positive signal observedResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>Blood pressure and vascular markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Women's health1 studiesTier-CMenstrual and women's healthSome positive signal observedFelt benefit focusPatient-group studyPotential benefit studied in Women's health.Open metrics>
Women's health
1 studiesTier-C
Menstrual and women's health
Some positive signal observedFelt benefit focusPatient-group study
Potential benefit studied in Women's health.
Open metrics
>Menstrual and women's health
No direct rate reported. Read direction and evidence strength together.
Evidence score
42.1
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Blood lipids1 studiesTier-CCholesterol and triglyceridesSome positive signal observedFelt benefit focusPatient-group studyPotential benefit studied in Blood lipids.Open metrics>
Blood lipids
1 studiesTier-C
Cholesterol and triglycerides
Some positive signal observedFelt benefit focusPatient-group study
Potential benefit studied in Blood lipids.
Open metrics
>Cholesterol and triglycerides
No direct rate reported. Read direction and evidence strength together.
Evidence score
41.4
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Recent research
Updated This Month10 new papers
10 new papers were added in this period. No new risk signal was identified.
What's new
10 new papers were added.No new risk signal was identified.
Most notable recent finding
This is the most meaningful new study in the latest update.
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paperStudy dosage range (reference only)
Lower dose
19.6
mg/dayHigher dose
37.5
mg/dayDosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.
Key cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Caution index
1.4
Caution band: Low
Caution signals
3
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.
Standalone side effects
Gastrointestinal Side Effects1 papers
Unabsorbed iron from high doses can cause gut irritation, inflammation, and dysbiosis, reducing compliance.human · systematic-reviewAdverse side effects (vs daily)1 papers
Women receiving intermittent iron supplements were less likely to have adverse side effects than those receiving daily supplements.human · systematic-reviewAdverse side effects1 papers
Women receiving intermittent iron supplements were more likely to have adverse side effects than those receiving no intervention or placebo.human · systematic-reviewEvidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
Key Evidence #2
observationalPublic scholarly dataCitation signal: 343
Deferiprone therapy was well tolerated and was associated with a reduced dentate and caudate nucleus iron content compared to placebo, which supports more extensive clinical trials into the potential benefits of iron chelation in PD.
Key Evidence #3
observationalPublic scholarly dataCitation signal: 249
Prophylactic antenatal oral iron supplements when given intermittently were not effective in preventing iron deficiency anaemia in pregnancy.
3 more summariesLimited representative sample by study type.>
Public scholarly dataCitation signal: 165
observationalAmong blood donors with normal hemoglobin levels, low-dose iron supplementation, compared with no supplementation, reduced time to 80% recovery of the postdonation decrease in hemoglobin concentration in donors with low ferritin (≤26 ng/mL) or higher ferritin
Public scholarly dataCitation signal: 160
observationalThis review considers the physiology of iron as a nutrient and how this physiology informs decision-making about weighing the benefits and risks of iron supplementation in iron-deficient, iron-sufficient, and iron-overloaded pregnant women and children.
Public scholarly dataCitation signal: 147
observationalIn patients with METS, phlebotomy, with consecutive reduction of body iron stores, lowered BP and resulted in improvements in markers of cardiovascular risk and glycemic control.
Iron
arrow_backBack to listEvidence score: 61.2|Caution index: 1.4