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Tier-BPublic-ready6/11/2026

Iodine

Menstrual and women's health is the main area connected here, and any felt benefit should be read together with the human evidence base.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
66.8
Menstrual and women's healthNutrient status markersCognition, memory, and focus

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Women's health
7 studiesTier-B
Menstrual and women's health
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Women's health.
Open metrics
>
Menstrual and women's health
No direct rate reported. Read direction and evidence strength together.
Evidence score
53.5
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status
6 studiesTier-B
Nutrient status markers
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
52.3
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Cognition and focus
3 studiesTier-C
Cognition, memory, and focus
Some positive signal observedFelt benefit focusPatient-group study
Potential benefit studied in Cognition and focus.
Open metrics
>
Cognition, memory, and focus
No direct rate reported. Read direction and evidence strength together.
Evidence score
42.1
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
review
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
1.1
Caution band: Low
Caution signals
1
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Standalone side effects

Adverse Events (Abortion, Blighted Ovum, Intrauterine Death, Neonatal Death)1 papers
The frequency of adverse events (abortion, blighted ovum, intrauterine death, neonatal death) did not differ between the iodine supplementation and placebo groups during gestation or at delivery.human · rct

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 59
review

The iodine requirements for pregnant and lactating women, how population iodine status can be assessed, the effects of maternal iodine deficiency and excess, and current data regarding efficacy of iodine supplementation for women who are pregnant or lactating

Key Evidence #2
Public scholarly dataCitation signal: 120
observational

Daily iodine supplementation in mildly iodine-deficient pregnant women had no effect on child neurodevelopment at age 5-6 years and was randomised using mixed-effects models.

Key Evidence #3
Public scholarly dataCitation signal: 90
observational

There is insufficient good-quality evidence to support current recommendations for iodine supplementation in pregnancy in areas of mild-to-moderate deficiency, and well-designed RCTs, with child cognitive outcomes, are needed in pregnant women who are moderate

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 65
review

Subclinical iodine deficiency persists even in Western Europe, especially among girls and women, being an issue in certain physiological conditions, such as pregnancy and lactation, and in people consuming unbalanced vegetable-based or salt-restricted diets.

Public scholarly dataCitation signal: 51
observational

Pregnant women in this region of Australia were unlikely to reach recommended iodine levels without an iodine supplement, even after the mandatory iodine supplementation of bread was instituted in October 2009.

Public scholarly dataCitation signal: 47
observational

Iodine supplementation in pregnancy did not result in better childhood neurodevelopment in this small trial and adequately powered randomised controlled trials are needed to provide conclusive evidence regarding the effect of iodine supplementation inregnancy.

Iodine
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