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arrow_backExplore/Hyaluronic Acid
Tier-CPublic-ready6/12/2026

Hyaluronic Acid

Bone, joint, and mobility is the main area connected here, and any felt benefit should be read together with the human evidence base.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
1.1
Bone, joint, and mobility

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Bone and joint health
1 studiesTier-C
Bone, joint, and mobility
Some positive signal observedFelt benefit focusPatient-group study
Potential benefit studied in Bone and joint health.
Open metrics
>
Bone, joint, and mobility
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
review
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.0
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Side-effect and combination signals

No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 110
review

A broad overview of different synthesis strategies used for modulating the biological as well as material properties of this polysaccharide plays a significant role in biomedical research and applications indicating the great promise for future innovative ther

Key Evidence #2
Public scholarly dataCitation signal: 726
review

This review describes metabolisms, different physi - ological and pathological functions, basic pharmacological properties, and the clinical use of hyaluronic acid.

Key Evidence #3
Public scholarly dataCitation signal: 337
review

This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 117
observational

It is shown that intranasal administration of exogenous Hyaluronidase is sufficient to release inter-α-inhibitor heavy chains, reduce lung hyaluronan content and restore lung function.

Public scholarly dataCitation signal: 54
unknown

Both hyaluronic acid and lactoferrin appear as reliable supports for the domiciliary management of periodontal disease, and paraprobiotics are likely to show the most important benefit thanks to their immunomodulating mechanism of action.

Public scholarly dataCitation signal: 49
observational

Differences in facial skin pH, sebum, elasticity, hydration and tonicity and serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins between patients affected by facial photoaging and healthy controls were assesse

Hyaluronic Acid
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