A broad overview of different synthesis strategies used for modulating the biological as well as material properties of this polysaccharide plays a significant role in biomedical research and applications indicating the great promise for future innovative ther
Hyaluronic Acid
Bone, joint, and mobility is the main area connected here, and any felt benefit should be read together with the human evidence base.
Representative tier calculated from paper evidence that passed the collection audit.
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Bone and joint health1 studiesTier-CBone, joint, and mobilitySome positive signal observedFelt benefit focusPatient-group studyPotential benefit studied in Bone and joint health.Open metrics>
Recent research
10 new papers were added in this period. No new risk signal was identified.
What's new
Most notable recent finding
Key cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Side-effect and combination signals
No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
This review describes metabolisms, different physi - ological and pathological functions, basic pharmacological properties, and the clinical use of hyaluronic acid.
This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.
3 more summariesLimited representative sample by study type.>
It is shown that intranasal administration of exogenous Hyaluronidase is sufficient to release inter-α-inhibitor heavy chains, reduce lung hyaluronan content and restore lung function.
Both hyaluronic acid and lactoferrin appear as reliable supports for the domiciliary management of periodontal disease, and paraprobiotics are likely to show the most important benefit thanks to their immunomodulating mechanism of action.
Differences in facial skin pH, sebum, elasticity, hydration and tonicity and serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins between patients affected by facial photoaging and healthy controls were assesse