Glycine

Tier-BPublic-ready7/5/2026

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed

Caution signal

Low

Representative score

58.4

Glucose and metabolic health markersBlood pressure and vascular health markersExercise performance and recovery

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health

4 studiesTier-B

Glucose and metabolic health markers

Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score

54.6

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood pressure and vascular health

2 studiesTier-C

Blood pressure and vascular health markers

Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score

48.7

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Exercise performance and recovery

2 studiesTier-C

Exercise performance and recovery

Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Exercise performance and recovery. These findings come from a defined study population, so everyday effects may differ.

Evidence score

29.9

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Sleep

1 studiesTier-C

Stress Response and Sleep Changes

Some positive signal observedFelt benefit focusSupplement context

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score

20.9

Study context

Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value

g/day

2 independent studies

Higher observed study value

g/day

Only ranges repeated in human, oral, single-ingredient studies are shown.

Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index

0.8

Caution band: Low

Caution signals

Side effects + combos + curated rules

Key precautions

No combination caution signal is clear enough to show right now. This does not guarantee safety.

1 combo signals and 0 added-signal combos shown below.

These are signals reported in studies. They do not predict what will happen to an individual.

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

NACIn a randomized clinical trial of older adults, GlyNAC (a combination of glycine and NAC) supplementation for 16 weeks improved glutathione deficiency, oxidative stress, and mitochondrial dysfunction compared to placebo.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1

Public scholarly dataCitation signal: 385

observational

Dietary supplementation with GSH precursor amino acids can restore GSH synthesis and lower oxidative stress and oxidant damage in the face of persistent hyperglycemia.

Key Evidence #2

Public scholarly dataCitation signal: 307

review

[Abstract]: Glycine is the proteinogenic amino-acid of lowest molecular weight, harboring a hydrogen atom as a side-chain. In addition to being a building-block for proteins, glycine is also required for multiple metabolic pathways, such as glutathione synthes

Key Evidence #3

Public scholarly dataCitation signal: 290

review

The ability of plants to accumulate high levels of GB in young tissues under abiotic stress, is independent of nitrogen (N) availability and supports the view that plant N allocation is dictated primarily to supply and protect the growing tissues, even under N

3 more summariesLimited representative sample by study type.

Public scholarly dataCitation signal: 290

rct

[Abstract]: Aging is associated with oxidative stress, but underlying mechanisms remain poorly understood. We tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress in aging and whether stimulating glut

Public scholarly dataCitation signal: 251

observational

In conclusion, dietary serine and glycine starvation has emerged as a potential therapy for cancer and inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion diet in mouse xenog

Public scholarly dataCitation signal: 244

observational

The authors provide experimental demonstration for the operation of the reductive glycine pathway in a natural microorganism, Desulfovibrio desulfuricans, which demonstrates microbial autotrophic growth fully supported by this highly ATP-efficient CO2 fixation

Glycine

Evidence score: 58.4|Caution index: 0.8

arrow_backBack to list