Key Evidence #1
reviewPublic scholarly dataCitation signal: 788
In studies using high-throughput metabolomics, several blood amino acids appear to be consistently associated with the risk of developing type 2 diabetes.
Tier-BPublic-ready6/13/2026
Glycine
Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.
Representative tier calculated from paper evidence that passed the collection audit.
Papers analyzed
20
Caution signal
Low
Representative score
67.4
Glucose and metabolic health markersImmune and respiratory supportCholesterol and triglycerides
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Glucose and metabolic health3 studiesTier-BGlucose and metabolic health markersFairly consistent positive signal in studiesResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Glucose and metabolic health
3 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
52.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Immune and respiratory health2 studiesTier-CImmune and respiratory supportSome positive signal observedFelt benefit focusSupplement contextPotential benefit studied in Immune and respiratory health.Open metrics>
Immune and respiratory health
2 studiesTier-C
Immune and respiratory support
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Immune and respiratory health.
Open metrics
>Immune and respiratory support
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.3
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Blood lipids1 studiesTier-CCholesterol and triglyceridesSome positive signal observedFelt benefit focusSupplement contextPotential benefit studied in Blood lipids.Open metrics>
Blood lipids
1 studiesTier-C
Cholesterol and triglycerides
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Blood lipids.
Open metrics
>Cholesterol and triglycerides
No direct rate reported. Read direction and evidence strength together.
Evidence score
40.5
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status1 studiesTier-CNutrient status markersSome positive signal observedResearch marker focusPatient-group studyThis card is closer to a measured biomarker or lab outcome than a directly felt user benefit.Closer to a research marker than a directly felt benefit.Open metrics>
Nutrient status
1 studiesTier-C
Nutrient status markers
Some positive signal observedResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
35.6
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Condition-specific evidence2 studiesTier-CCondition-specific health context in a specific contextSome positive signal observedResearch marker focusSupplement contextThis result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.Closer to a research marker than a directly felt benefit.Open metrics>
Condition-specific evidence
2 studiesTier-C
Condition-specific health context in a specific context
Some positive signal observedResearch marker focusSupplement context
This result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>Condition-specific health context
No direct rate reported. Read direction and evidence strength together.
Evidence score
27.1
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Sleep1 studiesTier-CStress Response and Sleep ChangesSome positive signal observedFelt benefit focusSupplement contextThese findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.Open metrics>
Sleep
1 studiesTier-C
Stress Response and Sleep Changes
Some positive signal observedFelt benefit focusSupplement context
These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.
Open metrics
>Sleep quality
No direct rate reported. Read direction and evidence strength together.
Evidence score
20.9
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Recent research
Updated This Month10 new papers
10 new papers were added in this period. No new risk signal was identified.
What's new
10 new papers were added.No new risk signal was identified.
Most notable recent finding
This is the most meaningful new study in the latest update.
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paperStudy dosage range (reference only)
Lower dose
2000
mg/dayHigher dose
2000
mg/dayDosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.
Key cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Caution index
0.3
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.
Side-effect and combination signals
No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
Key Evidence #2
reviewPublic scholarly dataCitation signal: 304
The present review aims at synthesizing the recent advances in glycine metabolism, pinpointing its main metabolic pathways, identifying the causes leading to glycine deficiency—especially in obesity and associated metabolic disorders— and evaluating the potent
Key Evidence #3
reviewPublic scholarly dataCitation signal: 108
It is highlighted how dietary glycine supplementation is important in avoiding the development of chronic inflammation by highlighting that glycine exerts its anti-inflammatory effects throughout the modulation of the expression of nuclear factor kappa B in ma
3 more summariesLimited representative sample by study type.>
Public scholarly dataCitation signal: 73
observationalTen weeks of EGML or GCE supplementation did not promote weight-loss or lower total cholesterol in overweight individuals consuming their habitual diet, although, EGML did increase plasma HDL-C levels which is associated with a lower risk of atherosclerosis.
Public scholarly dataCitation signal: 69
observationalIn conclusion, ingestion of collagen hydrolysates increases postprandial plasma concentrations of AAs over a period of 240 min, and an enzymatic hydrolysis increases the absorption rate and bioavailability of the collagen-rich AAs glycine, proline and hydroxyp
Public scholarly dataCitation signal: 63
observationalThe increased CSF cGP in Parkinson disease patients may result from the central uptake of plasma cGP, and the BCA has the potential to be developed to treat neurological conditions with IGF-1 deficiency.
Glycine
arrow_backBack to listEvidence score: 67.4|Caution index: 0.3