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Bio-Analyst

Research Platform
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Tier-BPublic-ready6/12/2026

Creatine

Exercise performance and recovery is the main area connected here, and any felt benefit should be read together with the human evidence base.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
73.4
Exercise performance and recoveryStress Response and Sleep ChangesCondition-specific health context in a specific context

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Exercise performance and recovery
9 studiesTier-A
Exercise performance and recovery
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Exercise performance and recovery.
Open metrics
>
Exercise performance and recovery
No direct rate reported. Read direction and evidence strength together.
Evidence score
78.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Stress and mood
2 studiesTier-C
Stress Response and Sleep Changes
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study
These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.
Open metrics
>
Stress and mood balance
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Condition-specific evidence
2 studiesTier-C
Condition-specific health context in a specific context
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Condition-specific health context
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Cognition and focus
2 studiesTier-C
Cognition, memory, and focus
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Cognition and focus.
Open metrics
>
Cognition, memory, and focus
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.3
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Fatigue and energy
1 studiesTier-C
Fatigue and energy
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Fatigue and energy.
Open metrics
>
Fatigue and energy
No direct rate reported. Read direction and evidence strength together.
Evidence score
42.1
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Bone and joint health
1 studiesTier-C
Bone, joint, and mobility
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Bone and joint health.
Open metrics
>
Bone, joint, and mobility
No direct rate reported. Read direction and evidence strength together.
Evidence score
42.1
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
review
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Study dosage range (reference only)

Lower dose
3
g/day
Higher dose
5
g/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.6
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Side-effect and combination signals

No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 698
review

An update to the current literature regarding the role and safety of creatine supplementation in exercise, sport, and medicine is provided and the position stand of International Society of Sports Nutrition (ISSN) is updated.

Key Evidence #2
Public scholarly dataCitation signal: 189
review

It is shown that creatine supplementation increases lean tissue mass and upper and lower body muscular strength during resistance training of older adults, but potential mechanisms by which creatine exerts these positive effects have yet to be evaluated extens

Key Evidence #3
Public scholarly dataCitation signal: 177
review

An internationally renowned team of research experts was formed to perform an evidence-based scientific evaluation of the literature regarding creatine supplementation, which shows that creatine supplementation is relatively well tolerated, especially at recom

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 134
review

There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors or chronic, pathologic conditions.

Public scholarly dataCitation signal: 130
review

Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral.

Public scholarly dataCitation signal: 116
review

The researchers attempted to review the literature on the effects of creatine supplementation and physical exercise on oxidative stress and found that creatine supplement consumption may have a synergistic effect with training, but the intensity and duration o

Creatine
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