biotech

Bio-Analyst

Research Platform
person
Tier-BPublic-ready7/4/2026

Citrulline

Exercise performance and recovery is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
76
Caution signal
Low
Representative score
78.0
Exercise performance and recoveryBlood pressure and vascular health markersGlucose and metabolic health markers

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Exercise performance and recovery
16 studiesTier-A
Exercise performance and recovery
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

Potential benefit studied in Exercise performance and recovery.

Evidence score
79.7
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood pressure and vascular health
7 studiesTier-B
Blood pressure and vascular health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
60.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Glucose and metabolic health
1 studiesTier-C
Glucose and metabolic health markers
Some positive signal observedResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
40.1
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Fatigue and energy
1 studiesTier-C
Fatigue and energy
Some positive signal observedFelt benefit focusSupplement context

Potential benefit studied in Fatigue and energy.

Evidence score
37.5
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
2.4
g/day
Higher observed study value
12
g/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.6
Caution band: Low
Caution signals
1
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Stomach discomfort1 papers
Stomach discomfort was reported as a side effect in 14.63% of subjects following a single 8g dose of citrulline malate.Human studies · Randomized controlled trial

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 213
review

The impact of supplementing this important urea cycle intermediate on cardiovascular and metabolic health outcomes is examined and future directions for investigating its therapeutic impact on cardiometabolic health are identified.

Key Evidence #2
Public scholarly dataCitation signal: 157
rct

[Abstract]: The purpose of the present study was to determine the effects of a single dose of citrulline malate (CM) on the performance of flat barbell bench presses as an anaerobic exercise and in terms of decreasing muscle soreness after exercise. Forty-one

Key Evidence #3
Public scholarly dataCitation signal: 139
rct

[Abstract]: The purpose of this study was to compare the effects of l-citrulline (Cit) and l-arginine (Arg) supplementation on nitric oxide (NO) biomarkers, pulmonary O2 uptake (V̇o2) kinetics, and exercise performance. In a randomized, placebo (Pla)-controlle

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 121
observational

This review aimed to investigate whether oral administration of the amino acids l-arginine and l-citrulline, which are potential substrates for eNOS, could effectively reduce BP by increasing NO production, and suggests that oral Arg supplementation can lower

Public scholarly dataCitation signal: 116
rct

[Abstract]: BackgroundMany human studies report that nitric oxide (NO) improves sport performance. This is because NO is a potential modulator of blood flow, muscle energy metabolism, and mitochondrial respiration during exercise. L-Citrulline is an amino acid

Public scholarly dataCitation signal: 103
rct

[Abstract]: The study sought to determine whether citrulline supplementation, a precursor to nitric oxide synthesis, is safe and efficacious in increasing plasma citrulline concentrations and decreasing the risk of postoperative pulmonary hypertension. Forty c

Citrulline
arrow_backBack to list