biotech

Bio-Analyst

Research Platform
person
arrow_backExplore/Citrulline
Tier-BPublic-ready6/12/2026

Citrulline

Blood pressure and vascular markers is the main area connected here, and any felt benefit should be read together with the human evidence base.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
68.0
Blood pressure and vascular markersExercise performance and recoveryGlucose and metabolic health markers

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Blood pressure and vascular health
4 studiesTier-B
Blood pressure and vascular markers
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study
Potential benefit studied in Blood pressure and vascular health.
Open metrics
>
Blood pressure and vascular markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
54.6
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Exercise performance and recovery
4 studiesTier-C
Exercise performance and recovery
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Exercise performance and recovery.
Open metrics
>
Exercise performance and recovery
No direct rate reported. Read direction and evidence strength together.
Evidence score
49.1
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Glucose and metabolic health
2 studiesTier-C
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Nutrient status
2 studiesTier-C
Nutrient status markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Condition-specific evidence
1 studiesTier-C
Condition-specific health context in a specific context
Some positive signal observedResearch marker focusSupplement context
This result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Condition-specific health context
No direct rate reported. Read direction and evidence strength together.
Evidence score
37.9
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Fatigue and energy
1 studiesTier-C
Fatigue and energy
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Fatigue and energy.
Open metrics
>
Fatigue and energy
No direct rate reported. Read direction and evidence strength together.
Evidence score
37.5
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
review
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Study dosage range (reference only)

Lower dose
1.2
g/day
Higher dose
6
g/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.0
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Side-effect and combination signals

No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 211
review

The impact of supplementing this important urea cycle intermediate on cardiovascular and metabolic health outcomes is examined and future directions for investigating its therapeutic impact on cardiometabolic health are identified.

Key Evidence #2
Public scholarly dataCitation signal: 121
observational

This review aimed to investigate whether oral administration of the amino acids l-arginine and l-citrulline, which are potential substrates for eNOS, could effectively reduce BP by increasing NO production, and suggests that oral Arg supplementation can lower

Key Evidence #3
Public scholarly dataCitation signal: 115
observational

Oral L-citrulline supplementation reduced the time take to complete a cycle ergometer exercise trial and significantly improved subjective feelings of muscle fatigue and concentration immediately after exercise.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 54
observational

L-citrulline can have therapeutic benefits in diabetic patients through increasing NO levels and thus maintaining vascular function possibly through an arginase inhibition related pathway, as shown in patients with type 2 diabetes mellitus.

Public scholarly dataCitation signal: 51
observational

[Abstract]: What is the central question of this study? Does short‐term supplementation with l‐citrulline in order to increase l‐arginine improve exercise blood flow and peripheral dilatation responses to exercise in older adults? What is the main finding and

Public scholarly dataCitation signal: 46
observational

CIT supplementation when combined with HIIT seems to induce greater improvements in upper limbs muscle strength and walking speed in dynapenic-obese elderly.

Citrulline
arrow_backBack to list