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Tier-CPublic-ready6/13/2026

Betaine

Nutrient status markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
20
Caution signal
Low
Representative score
54.8
Nutrient status markersGlucose and metabolic health markersCholesterol and triglycerides

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Nutrient status
2 studiesTier-C
Nutrient status markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Nutrient status and deficiency markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
48.7
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Glucose and metabolic health
2 studiesTier-C
Glucose and metabolic health markers
Some positive signal observedResearch marker focusSupplement context
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.3
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Blood lipids
1 studiesTier-C
Cholesterol and triglycerides
Some positive signal observedFelt benefit focusPatient-group study
Potential benefit studied in Blood lipids.
Open metrics
>
Cholesterol and triglycerides
No direct rate reported. Read direction and evidence strength together.
Evidence score
44.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Men's health
1 studiesTier-C
Male Reproductive Health Markers
Some positive signal observedResearch marker focusSupplement context
These findings come from sperm, semen, or hormone markers such as testosterone, LH, FSH, and inhibin B. They are closer to research measurements than a directly felt benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Male reproductive and hormone markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
38.5
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Condition-specific evidence
1 studiesTier-C
Condition-specific health context in a specific context
Some positive signal observedResearch marker focusSupplement context
This result was studied for Condition-specific health context in a narrower population or condition-specific context. It should not be generalized as an everyday supplement effect.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Condition-specific health context
No direct rate reported. Read direction and evidence strength together.
Evidence score
28.2
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Exercise performance and recovery
2 studiesTier-C
Exercise performance and recovery
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Exercise performance and recovery.
Open metrics
>
Exercise performance and recovery
No direct rate reported. Read direction and evidence strength together.
Evidence score
23.5
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
observational
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Study dosage range (reference only)

Lower dose
2
g/day
Higher dose
2.5
g/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.6
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Side-effect and combination signals

No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 78
observational

It is shown that an egg intervention improved linear growth by a length-for-age z score of 0.63 and supported the hypothesis that early introduction of eggs significantly improved choline and other markers in its methyl group metabolism pathway.

Key Evidence #2
Public scholarly dataCitation signal: 110
observational

Plasma metabolite profiling in the Diabetes Prevention Program indicates betaine is a marker of diabetes risk among high-risk individuals both at baseline and during preventive interventions and they complement animal models demonstrating a direct role for bet

Key Evidence #3
Public scholarly dataCitation signal: 44
review

Chronic betaine consumption may increase heat tolerance and provide another avenue of supplementation for those who find that heat stress is a major factor in their work, or training for exercise and sport, yet this remains speculative until data demonstrate s

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 43
observational

Betaine supplementation increased testosterone levels and T/C ratio in youth professional soccer players during a competitive season and had no negative effects on growth and may attenuate reductions in testosterone due to intense training during puberty.

Public scholarly dataCitation signal: 42
observational

A trial using two dietary supplements, betaine and folic acid, to promote global levels of methylation and attempt to activate the paternally inherited UBE3A gene, which is essential to prevent AS.

Public scholarly dataCitation signal: 42
observational

The present systematic review and meta-analysis supports the advantage of a lower dose of betaine supplementation (<4 g/d) on homocysteine concentrations without the lipid-augmenting effect observed with a higher dosage.

Betaine
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